| 溶菌酶的结构与功能 |
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| 引用本文： | 丁昌玉. 溶菌酶的结构与功能[J]. 蚌埠医学院学报, 1986, 0(4) |
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| 作者姓名： | 丁昌玉 |
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| 作者单位： | 蚌埠医学院生化教研室 |
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| 摘 要： | 本文讨论了溶菌酶的基本结构及其三维空间结构,从它的结构特点阐述其溶解细菌作用的机理。溶菌酶是第一个结构弄清楚的酶,其一级结构为129个氨基酸残基组成的单一多肽链。它经盘绕折叠形成二级及三级结构,使得此酶具有一个椭球形的外形,其上的裂隙是该酶的活性部位。当底物(细菌细胞壁)结合在此处时,细菌即被溶解,说明了酶的功能是由其结构决定的,在临床上可测定血及尿中此酶含量协助诊断白血病,并可用它来治疗一些疾病。
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| 关 键 词： | 溶菌酶 一级结构 三维空间结构 活性部位 |
STRUCTURE AND FUNCTION OF LYSOZYME |
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| Ding Changyu. STRUCTURE AND FUNCTION OF LYSOZYME[J]. Journal of Bengbu Medical College, 1986, 0(4) |
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| Authors: | Ding Changyu |
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| Abstract: | The primary and three dimensinal structure of lysozyme was described. The mechanism of bacteriolysis was investigated from its structural feature. The enzyme consists of a single polypeptide chain with 129 ami-noacid residuses. The polypeptide chain can be folded into a-helical and pleated sheet regions which are termed the secondary structure, forms tertiary structure. Lysozyme is an ellipse globular shape molecule. There is a cleft between two halves of the molecule, which is the active side of lysozyme. The enzyme attaches itself lo the bacteria cell wall. ]t is suggested that the function of lysozyme is decided by its structure, and the content of lysozyme in blood and urea can be determind. It will help, to make a diagnosis of leukemia in clinical practice. |
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| Keywords: | lysozyme primary structure three dimensinae structure active site |
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