奥曲肽治疗食道胃底静脉曲张破裂出血的疗效

目的 观察奥曲肽治疗肝硬化患者食管胃底静脉曲张破裂出血的疗效.方法 将56例患者随机分为治疗组和对照组,各28例;治疗组使用奥曲肽,对照组使用垂体后叶素,于治疗12、24、48、72h后观察止血率、再出血率、不良反应发生率及死亡率.结果 治疗组在不同时间点的止血率明显高于对照组(P＜0.01),而再出血率、不良反应发生率及死亡率均显著低于对照组(P＜0.01).结论 奥曲肽可显著降低患者的出血和死亡率,其不良反应发生率也显著降低,是控制肝硬化患者食管胃底静脉曲张破裂出血的有效药物.

Effects of Octreotide on Treatment of Hemorrhage from Esophageal-fundal Varices

Objective To investigate the effect of octreotide on the treatment of acute hemorrhage from esophageal-fundal varices in patients with liver cirrhosis. Methods 56 patients with acute hemorrhage from esophageal-fundal varices as a result of liver cirrhosis were randomly classified into treatment and control groups (n=28). Patients in treatment group were treated with octreotide, while control patients were treated with vasopressin. Hemostasis, re-hemorrhage, and side-effects were determined 12, 24, 46 and 72h after treatment. Results The effect of hemostasis in octreotide-treated patients was better than controls (P < 0.01). Re-hemorrhage, side-effects, and mortality was also significantly decreased in octreotide-treated group than that in controls (P< 0.01). Conclusion Octreotide can effectively decrease hemorrhage and mortality in patients with acute hemorrhage from esophageal-fundal varices, and its side-effects were also significantly lower than that of control. It is a safe drug to treat acute hemorrhage from esophageal-fundal varices in patients with liver cirrhosis.