| 卵巢克鲁根勃瘤及卵巢癌P~(53)ER PR表达的研究 |
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| 引用本文： | 何家玉,戴瑜珍,张菊华.卵巢克鲁根勃瘤及卵巢癌P~(53)ER PR表达的研究[J].皖南医学院学报,1999(2). |
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| 作者姓名： | 何家玉 戴瑜珍 张菊华 |
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| 作者单位： | 安庆市第一人民医院，附属弋矶山医院病理科 |
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| 摘 要： | 应用免疫组织化学BSA法检测32例卵巢克鲁根勃瘤、20例卵巢癌中P53蛋白、雌激素受体（ER）、孕激素受体（PR），其阳性表达率克鲁根勃瘤分别10.9％（13／32）、21.9％（7／32）、21．9％（7／32），卵巢癌依次为45％（9／20）、65％（13／20）、50％（10／20）。结果表明P53在两者中阳性表达率无显著相关性，ER、PR在高分化卵巢癌中阳性表达率明显高于克鲁根勃瘤及低分化卵巢癌（P＜0．001）。在卵巢癌中ER、PR阳性表达率与组织学分化程度正相关（P＜0．05）与预后负相关（P＜0．01）。
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| 关 键 词： | 卵巢肿瘤 克鲁根勃瘤 蛋白P~(53) 雌激素受体 孕激素受体 |
Analysis of the P~(53) Expression and Detecting ER,PR in Krukenberg's Tumor and Ovarian Cancer |
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| He Jiayu, Dai Yuzhen, Zhang Juhua.Analysis of the P~(53) Expression and Detecting ER,PR in Krukenberg's Tumor and Ovarian Cancer[J].Acta Academiae Medicinae Wannan,1999(2). |
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| Authors: | He Jiayu Dai Yuzhen Zhang Juhua |
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| Abstract: | Using BSA immunohistochemical methods, the P53 ER and PR in 32 cases of krukenberg's tumor and 20 cases of ovarian cancer were detected. The positive rate of P53 ER, PR in krukenberg's tumor and ovarian cancer were 40. 9% (13/32) Vs 45. 0% (9/20); 2l. 9% (7/32) Vs 65.0%(13/20) and 21. 9(7/20) Vs50% (10/20) respectively. There was no significant difference between krukenberg's tumor and ovarian cancer in the expression of P53,but the expression of ER and PR in high grade ovarian cancer was much higher than that in lower grade ovarian cancer and krukenberg's tumor. Expression of the ER and PR was correlated with differenciation and prognasis of the ovarian cancer. |
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| Keywords: | ovarian neoplasms krukenberg's tumor P~(53) protein estrogen receptors progesterone receptor |
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