| 川芎嗪对类风湿性关节炎患者PBMC免疫球蛋白合成的影响 |
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| 引用本文： | 王建杰,罗文哲,张涛,孟祥冬,任永波,梁立春.川芎嗪对类风湿性关节炎患者PBMC免疫球蛋白合成的影响[J].黑龙江医药科学,2004,27(4):15-15. |
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| 作者姓名： | 王建杰 罗文哲 张涛 孟祥冬 任永波 梁立春 |
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| 作者单位： | 佳木斯大学基础医学院免疫教研室,黑龙江,佳木斯,154007 |
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| 摘 要： | 目的：探讨川芎嗪对培养的类风湿性关节炎(RA)活动期、静止期外周血单个核细胞(PBMC)产生免疫球蛋白(Ig)的影响。方法：应用细胞培养技术，采用ELISA检测方法，检测细胞培养上清液IgG、IgM的含量。结果：川芎嗪明显抑制类风湿性关节炎活动期及静止期IgG、IgM的合成。结论：川芎嗪可以抑制RA患者中IgG、IgM的合成，可减轻RA的发展。
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| 关 键 词： | 类风湿性关节炎 PBMC 免疫球蛋白 |
| 文章编号： | 1008-0104(2004)04-0015-01 |
| 修稿时间： | 2004年5月24日 |
Effects of Ligustrazin on the synthesis of immunoglobulins in peripheral blood mononuclear cells of patients with rheumatoid arthritis |
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| WANG Jian-jie,LUO Wen-zhe,ZHANG Tao,MENG Xiang-dong,REN Yong-bo,LIANG Li-chun.Effects of Ligustrazin on the synthesis of immunoglobulins in peripheral blood mononuclear cells of patients with rheumatoid arthritis[J].Heilongjiang Medicine and Pharmacy,2004,27(4):15-15. |
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| Authors: | WANG Jian-jie LUO Wen-zhe ZHANG Tao MENG Xiang-dong REN Yong-bo LIANG Li-chun |
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| Abstract: | Objective: Regulatory effects of Ligustrazin on the synthesis of immunoglobulins in peripheral blood mononuclear cells (PBMC) cultured in the active and static stages of rheumatoid arthritis (RA). Methods: The levels of IgG and IgM in the cultured cell were assayed by ELISIA . Results: Ligustrazin obviously restrained the synthesis of IgG and IgM in the active and static stages of RA. Conclusion: Ligustrazin can restrain the synthesis of IgG and IgM of RA patients, which contribute to the improvement of the condition of RA patients. |
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| Keywords: | rheumatoid arthritis peripheral blood mononuclear cells immunoglobulin |
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