老年糖尿病患者合并尿路感染的病原菌分布及耐药性分析

目的分析本院老年糖尿病患者合并尿路感染病原菌分布及耐药性，为临床合理应用抗菌药物提供科学依据。方法分析本院2008年1月～2010年12月266例老年糖尿病合并尿路感染患者尿培养分离出302株病原菌及其耐药性。结果老年糖尿病合并尿路感染的菌株以革兰阴性杆菌为主，199株（65．9％），其次是革兰阳性球菌，87株（28．8％）和真菌，16株（5．3％），耐药菌株比率呈上升趋势。结论老年糖尿病患者合并尿路感染病原菌以大肠埃希菌为主，其次为凝固酶阴性葡萄球菌、肺炎克雷伯菌、肠球菌、铜绿假单胞菌、金黄色葡萄球菌、真菌，耐药率呈上升趋势，多重耐药现象普遍存在，对老年糖尿病合并尿路感染的病原菌及其耐药性监测，可为老年糖尿病患者尿路感染的诊治提供依据。

Distribution and antimicrobial resistance of pathogens of aged diabetic patients with urinary tract infection

Objective To Analys the pathogen distribution and drug resistance of aged diabetic patients with urinary tract infection to provide a reasonable reference for using antibiotics in clinic.Methods A retrospective study was carried out the distribution and resistance rates of 302 bacteria trains isolated from wounds of 266 aged diabetic patients with urinary tract infection from Jan 2008 to Dec 2010.Results Gram negative bacteria accounting for 65.9%,Gram-positive bacteria accounting for 28.8%and fungi accounting for 5.3% its were prevalent in the aged diabetic patients with urinary tract infection,the proportion of resistant strains was increasing.Conclusion Escherichia colis are predominant in aged diabetic patients with urinary tract infection,followed by coagulase-negative staphylococci,Klebsiella pneumoniae,Enterococcus,Pseudomonas aeruginosa,Staphylococcus aureus,Fungi,the proportion of resistant strains was increasing multidrug resistance is a common phenomenon.It is important to survey pathogens and their antibiotic resistance in aged diabetic patients with urinary tract infection.