无锡市甲型H1N1流感及季节性流感疫苗接种效果分析

目的调查流感样病例(ILI)和无锡市一般人群中甲型H1N1流感疫苗及季节性流感疫苗的接种情况,评估疫苗接种后对人群的保护效果。方法以无锡市2家哨点医院为基础,采集流感样病例病毒核酸检测阳性的病例作为病例组,共1 529人,同时按照"病例"的电话信息,随机产生电话号码选择、年龄匹配的一般人群作为对照组,共380人。结果病例组甲型H1N1流感疫苗接种率为6.1%(94/1 529),对照组甲型H1N1流感疫苗接种率为12.1%(46/380),两组比较,差异有统计学意义(P0.01);甲型H1N1流感病例中接种甲型H1N1流感疫苗的比例为12.5%(3/24),门诊检测阴性的ILI病例接种甲型H1N1流感疫苗的比例为6.1%(78/1 273),"接种甲型H1N1流感疫苗"因素的OR值为0.457(P=0.201);以电话调查一般人群(330例)作为对照组,接种甲型H1N1流感疫苗的比例为13.3%(44/330),OR值为1.077(P=0.908)。结论该次调查说明接种甲型H1N1流感疫苗对预防流感样病例有一定效果,但由于样本量较少,24种方法病例对照分析均未得出差异有统计学意义。

Analysis on immune effect of influenza A(H1N1) and seasonal influenza vaccines in Wuxi

Objective]To investigate the vaccination rate of influenza A(H1N1) and seasonal influenza vaccines in influenza-like illness(ILI) cases and general population,evaluate the protective effect of vaccines.Methods]1 529 ILI cases who were positive for influenza virus were collected from 2 sentinel hospitals in Wuxi city,which was the case group.380 age-matched people(the control group) were randomly collected according to the cases’ telephone number.Results]The coverage rate of influenza A(H1N1) vaccine in the case group and the control group was respectively 6.1%(94/1 529) and 12.1%(46/380),and the difference between two groups was significant(P<0.01) The vaccination rate of influenza A(H1N1) vaccine in patients with influenza A(H1N1) was 12.5%(3/24),and that in ILI cases with negative detection results was 6.1%(78/1 273).OR value of"vaccinated with influenza A(H1N1) vaccine"was 0.457(P=0.201).The vaccination rate of influenza A(H1N1) vaccine in the control group(330 people) was 13.3%(44/330),and OR value was 1.077(P=0.908).Conclusion]This investigation shows that influenza A(H1N1) vaccine had certain effect in preventing ILI cases.Because the sample size is small,no significant difference is found by 24 case-control analysis methods.