| 三硝基甲苯对大鼠睾丸某些生化功能的影响 |
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| 引用本文： | 常元勋,崔京伟,杨润宽,周威,赵春艳,田瑞泉,江泉观.三硝基甲苯对大鼠睾丸某些生化功能的影响[J].工业卫生与职业病,1994(1). |
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| 作者姓名： | 常元勋 崔京伟 杨润宽 周威 赵春艳 田瑞泉 江泉观 |
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| 作者单位： | 北京医科大学劳动卫生教研室 |
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| 摘 要： | 本研究采用急性染毒方式，观察三硝基甲苯（ＴＮＴ）对大鼠睾丸某些生化功能的影响。结果表明，２０００ｍｇ／ｋｇＴＮＴ染毒组睾丸葡萄糖－６－磷酸脱氢酶（Ｇ－６－ＰＤ）、乳酸脱氢酶（ＬＤＨ）、山梨醇脱氢酶（ＳＤＨ）和酸性磷酸酶（ＡＣＰ）活性下降，睾丸锌含量下降，而血清锌含量上升。１０００ｍｇ／ｋｇＴＮＴ染毒组睾丸Ｇ－６－ＰＤ和ＡＣＰ活性也下降，而血清锌含量升高。表明睾丸中Ｇ－６－ＰＤ和ＡＣＰ活性以及血清锌含量变化较为敏感。
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| 关 键 词： | 葡萄糖－6－磷酸脱氢酶 酸性磷酸酶，血清和睾丸锌 三硝基甲苯 |
CHANGES OF CERTAIN BIOCHEMICAL FUNCTION IN RATS EXPOSED ACUTELY TO TRINITROTOLUENE |
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| Chang Yuanxun, et al.CHANGES OF CERTAIN BIOCHEMICAL FUNCTION IN RATS EXPOSED ACUTELY TO TRINITROTOLUENE[J].Industrial Health and Occupational Diseases,1994(1). |
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| Authors: | Chang Yuanxun |
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| Institution: | Chang Yuanxun; et al |
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| Abstract: | The changes of certain biochemical functions in rats exposed acutely toTNT were investigated. The results showed that the activities of G-6-PD ,LDH, SDH and ACP of rat testes were lower than those of controls at dose of 2000mg/kg TNT. The testicular zinc contents were lower, while serum zinc contents were higher than those of controls at dose of 2000mg/kg TNT. At dose of 1000mg/kg TNT, the activities of G-6-PD and ACP of rat testes were decreased too, while the serum zinc contents still increased. This study indicated that the changes of the activities of G-6-PD and ACP of rat testesand the contents of serum zinc were more sensitive to TNT toxicity. |
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| Keywords: | glucose-6-phosphate dehydrogenase acid phosphases serum and testicular zinc trinitrotoluene |
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