Liver disease after hematopoietic cell transplantation in adults |
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| Institution: | 1. Department of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Coro West, Suite 402H, 1 Hoppin Street, Providence, RI 02903, USA;2. Department of Orthopaedics, the Second Hospital of Shanxi Medical University, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, Taiyuan, China;3. Department of Surgery, Boston University, Roger Williams Medical Center, Providence, RI 02908, USA;4. Department of Dermatology Biology, Boston University, Roger Williams Medical Center, Providence, RI 02908, USA |
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| Abstract: | Liver-related complications constitute a large component of the overall morbidity and mortality associated with hematopoietic cell transplantation. Affecting up to 80% of allogeneic HCT recipients, prompt recognition and treatment are essential. The differential diagnosis is broad and is best categorized by time of onset after transplantation. Early complications include drug-induced liver injury, sinusoidal obstruction syndrome, and graft-versus-host disease. Late complications include infectious sequelae, cirrhosis, and hepatic malignancies. Patients being considered for hematopoietic cell transplantation should be screened and evaluated for liver-related complications to help improve outcomes. |
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