Long-term safety and efficacy of varicella vaccination in children with juvenile idiopathic arthritis treated with biologic therapy |
| |
| Affiliation: | 1. Department of Allergology, Rheumatology and Clinical Immunology, University Children''s Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia;2. Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia;1. Department of pharmacy, CHU de Toulouse, 330, avenue de Grande-Bretagne, 31059 Toulouse cedex 9, France;2. Department of geriatric medicine, CHU de Toulouse, 224, avenue de Casselardit, 31059 Toulouse cedex 9, France;3. Department of pneumology and allergology, CHU de Toulouse, 24, chemin de Pouvourville, 31059 Toulouse cedex 9, France;1. Department of internal medicine, Seoul national university college of medicine, 101, Daehag-ro, 03080 Jongno-gu, Seoul, Republic of Korea;2. Department of clinical pharmacology and therapeutics, Seoul national university college of medicine, Seoul, Republic of Korea;3. Department of laboratory medicine, Seoul national university college of medicine, Seoul, Republic of Korea;1. National Center for Immunizations and Respiratory Diseases, Division of Bacterial Diseases, CDC, United States;2. Epidemic Intelligence Service, Center for Surveillance, Epidemiology, and Laboratory Services Division of Scientific Education and Professional Development, CDC, United States;3. Penobscot County Department of Health, Bangor, ME, United States;4. Maine State Health Department, United States;1. Department of Women''s and Children''s Health, Karolinska Institutet, Stockholm, Sweden;2. Pediatric Emergency Department, Astrid Lindgren Children''s Hospital, Stockholm, Sweden;3. Pediatric Rheumatology Unit, Astrid Lindgren Children''s Hospital, Stockholm, Sweden;1. Department of Paediatrics, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, India;2. Consultant Physician and Nephrologist, Apollo DRDO Hospital, Hyderabad, Telangana, India;3. Department of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, India;4. Indian Immunologicals Limited, Hyderabad, Telangana, India;1. Hospital del Niño Panama, Panama City, Panama;2. Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama City, Panama;3. Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT), Panama City, Panama;4. GSK Vaccines, CARICAM ANDINA, Panama City, Panama;5. GSK Pharmaceuticals Limited, Bangalore, India;6. GSK Vaccines, LATAM, Panama City, Panama;7. GSK Vaccines, LATAM, Bogotá, Colombia |
| |
| Abstract: | ObjectiveTo evaluate the long-term safety and efficacy of varicella vaccination in children with juvenile idiopathic arthritis (JIA) treated with biologics.MethodsWe performed a prospective study with long term follow up. Six patients with JIA treated with biologics, received 2 doses of varicella vaccine. Before vaccination, JIA was stable on therapy and peripheral blood lymphocyte populations were within normal limits. After vaccination, children were followed for disease activity, infections and production of protective antibodies.ResultsThere were no serious side effects after vaccination and no varicella infection. Disease activity remained stable. Five patients (83%) produced protective antibodies against varicella virus 6 weeks after the second vaccination. One patient with low level of protective antibodies got mild varicella infection 4 months after the second vaccination.ConclusionVaricella vaccination appears to be safe in our group of six JIA patients treated with biologics. Vaccination does not always protect against varicella infection. |
| |
| Keywords: | Varicella vaccination Juvenile idiopathic arthritis Biologic therapy |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
