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Novel vaccine concept based on back-boost effect in viral infection
Institution:1. School of Engineering and Applied Science, Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom;2. School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom;3. Department of Computer Science, The Islamia University of Bahawalpur, Punjab, Pakistan;1. Department of Microbiology, Faculty of Medicine Siriraj Hospital, Thailand;2. Faculty of Medical Technology, Mahidol University, Thailand;3. Division of Molecular Medicine, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Thailand;1. Reproductive Endocrinologist, Department of Internal Medicine, Shahrood Branch, Islamic Azad University, Shahrood, Iran;2. Obstetrics and Gynecologist,Department Of Obstetrics & Gynecology, Sharood Branch, Islamic Azad University, Shahrood, Iran;3. Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran;1. Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel;2. Department of Immunology, Weizmann Institute of Science, Rehovot, Israel;1. Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea;2. Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Republic of Korea;3. Department of Statistics, Seoul National University, Seoul, Republic of Korea;4. Department of Laboratory Medicine and Genetics, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea;5. Seoul National Hospital, Seoul, Republic of Korea;6. Yong-In Mental Hospital, Kyunggi-Do, Republic of Korea;7. Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea
Abstract:A novel vaccine concept is discussed based on recent evidence of a “back-boost” effect in Influenza infection. The initial immune response to the infection is imprinted through an immune memory pathway. The immune memory in the back-boost mechanism could be used in reversed order as a “forward-boost” in the proposed vaccine concept.
Keywords:Viral infection  Influenza  HIV-1  Deceptive imprinting  Antibody  Vaccine
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