Association between mixed rotavirus vaccination types of infants and rotavirus acute gastroenteritis |
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| Institution: | 1. Pediatric Emergency Medicine Associates, Atlanta, GA, USA;2. Morehouse School of Medicine, Departments of Microbiology/Biochemistry/Immunology and Pediatrics, Atlanta, GA, USA;3. Emory University, Department of Pediatrics, Atlanta, GA, USA;4. Emory University, Rollins School of Public Health, Department of Biostatistics and Bioinformatics, Atlanta, GA, USA;5. Emory University, Department of Medicine, Atlanta, GA, USA;6. Emory University, Department of Pathology and Laboratory Medicine, Atlanta, GA, USA;7. Children''s Healthcare of Atlanta, Atlanta, GA, USA;1. Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain;2. Liver Disease and Hepatitis Program, Alaska Native Medical Center, Anchorage, AK, United States;1. International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea;2. Regional Medical Research Center (ICMR), Chandrasekharpur, Bhubaneswar 751-023, Odisha, India;3. Directorate of Health Services, Bhubaneswar, Odisha, India;1. Servicio de Nefrología, Complejo Asistencial de Segovia, Segovia, Spain;2. Servicio de Análisis Clínicos, Complejo Asistencial de Segovia, Segovia, Spain;3. Centro Nacional de Microbiología, Majadahonda, Madrid, Spain;4. Servicio de Nefrología, Hospital Clínico Universitario de Salamanca, Salamanca, Spain;5. Servicio de Digestivo, Complejo Asistencial de Segovia, Segovia, Spain |
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| Abstract: | IntroductionRotavirus remains the leading cause of severe diarrhea in children under 5 years worldwide. In the US, Rotarix® (RV1) and RotaTeq® (RV5), have been associated with reductions in and severity of rotavirus disease. Studies have evaluated the impact of RV1 or RV5 but little is known about the impact of incomplete or mixed vaccination upon vaccine effectiveness.MethodsCase control study to examine association of combined RV1 and RV5 and rotavirus acute gastroenteritis, factoring severity of diarrheal disease. Children born after March 1, 2009 with acute gastroenteritis from three pediatric hospitals in Atlanta, Georgia were approached for enrollment. Survey was administered, stool specimen was collected, and vaccination records were obtained.Results891 of 1127 children with acute gastroenteritis were enrolled. Stool specimens were collected from 708 for rotavirus testing; 215 stool samples tested positively for rotavirus. Children >12 months of age were more likely to have rotavirus. Children categorized with Vesikari score of >11 were almost twice as likely to be rotavirus positive. Prior rotavirus vaccination decreased the mean Vesikari score, p < 0.0001. Children with complete single type vaccination were protected against rotavirus (OR 0.21, 95% CI: 0.14–0.31, p < 0.0001).ConclusionComplete rotavirus vaccination with a single vaccine type resulted in protection against rotavirus diarrhea and decrease in severity of rotavirus gastroenteritis. Incomplete rotavirus vaccination either with a single vaccine or mixed vaccination types also provided some protection. |
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| Keywords: | Rotavirus Rotavirus vaccination Acute gastroenteritis Pediatric |
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