Cyclin E amplification/overexpression is associated with poor prognosis in gastric cancer |
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| Affiliation: | 1. Department of Oncology, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona (UAB), Barcelona;2. Department of Oncology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona;3. Department of Pathology, Vall d''Hebron University Hospital, Universitat Autònoma de Barcelona (UAB), Barcelona;4. General and Digestive Surgery Department, Vall d''Hebron University Hospital, Universitat Autònoma de Barcelona (UAB), Barcelona;5. Radiation Oncology Department, Vall d''Hebron University Hospital, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain;6. Human Oncology and Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, USA |
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| Abstract: | We describe the correlation between cyclin E and HER2 amplification/overexpression and the clinical outcome in 87 patients with gastric cancer (GC) treated with surgery and adjuvant treatment at our centre. We observed that cyclin E and HER2 amplification/overexpression are not mutually exclusive, and that cyclin E amplification/overexpression correlates with poor prognosis. The co-amplification of cyclin E and HER2 in GC warrants prospective evaluation given the reported role of cyclin E in limiting the effectiveness of anti-HER2 therapies. |
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