Quantitative Bone Ultrasound at the Distal Radius in Adults with Cystic Fibrosis |
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| Affiliation: | 1. Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Avenida Dr. Eneas de Carvalho Aguiar, 44-05403-900, Sao Paulo, Brazil;2. Hospital Israelita Albert Einstein, Sao Paulo, Brazil;3. Rusculleda Foundation for Research, DAMIC Medical Institute, Cordoba, Argentina;4. Pharmacology Department, FASTA University, School of Medicine, Mar del Plata, Argentina;5. Facultad de Ciencias de la Salud, Universidad Nacional de Formosa, Formosa, Argentina;6. Universidad of Salvador, Buenos Aires, Argentina;7. Hospital Alta Complejidad El Cruce, UNLP, Argentina;8. Centro Universitario Estacio de Ribeirao Preto, Ribeirao Preto, Sao Paulo, Brazil;9. Lipids, Atherosclerosis, and Vascular Biology Section, Cardiology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil;10. Hospital Universitario Onofre Lopes (HUOL), Universidade Federal do Rio Grande do Norte, Natal, Brazil;11. Laboratorio de Lipides (LIM-10), Hospital das Clínicas (HCFMUSP) da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil;12. Hospital Israelita Albert Einstein, Sao Paulo, Brazil;13. Center for Advanced Metabolic Medicine and Nutrition, Santiago, Chile;14. Hospital Carlos Andrade Marin and Hospital Alianza, Quito, Ecuador;15. Departments of Internal Medicine and of Clinical Epidemiology, School of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia;p. Metabolic Diseases Study Group, Department of Internal Medicine, Universidad del Cauca, Popayán, Colombia;q. Hospital Universitario Fundación Santa Fe de Bogotá, Universidad de los Andes, Universidad El Bosque, D.C., Bogotá, Colombia;r. Hospital Universitario San Vicente Fundación, Universidad de Antioquia, Medellín, Colombia |
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| Abstract: | It is of clinical importance to identify bone disease related to cystic fibrosis (CF) early in its course to allow therapeutic interventions that optimize bone health. To test the technical (precision) and clinical (percentage of abnormal results, correlation with clinical parameters) performance of a commercial quantitative ultrasound apparatus for radial measurements, speed of sound (SOS) was measured at the distal third of the left radius with the Omnisense 7000p apparatus (Sunlight Medical, Tel-Aviv, Israel) in a group of young adult CF patients with regular follow-up at the Brussels and Ghent University Hospital. Sixty-three (37 males) CF patients at a median (range) age of 23.5 y (18.1–39.9) were included. SOS, SOS z-score and SOS t-score were respectively 4017 ± 97 m/s, −0.31 ± 0.74 and −0.60 ± 0.78 in males and 4086 ± 97 m/s, −0.19 ± 0.75 and −0.51 ± 0.95 in females. Mean SOS t-score was significantly lower compared with the manufacturer's reference data for males (p < 0.0001) and females (p = 0.01). SOS z- and t-scores correlated with weight z-score and body mass index z-score in females. No significant correlation was found between SOS and forced expiratory volume in 1 s (%). Neither diabetes mellitus nor liver disease was found to influence SOS. Radial quantitative ultrasound has a precision of 0.55%. The SOS is in the low normal range in 14% of CF patients and is influenced by weight in female patients, but not by the severity of the lung disease. |
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| Keywords: | Quantitative ultrasound Cystic fibrosis Bone mineral density Osteoporosis Malnutrition |
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