Rol de los microARN en las enfermedades pulmonares |
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| Authors: | Martí n Angulo,Emilia Lecuona,Jacob Iasha Sznajder |
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| Affiliation: | 1. Division of Pulmonary and Critical Care, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, EE. UU;2. Departamento de Fisiopatología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay |
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| Abstract: | MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively regulate gene expression. They actively participate in the modulation of important cell physiological processes and are involved in the pathogenesis of lung diseases such as lung cancer, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease. A better understanding of the role that miRNAs play in these diseases could lead to the development of new diagnostic and therapeutic tools. In this review, we discuss the role of some miRNAs in different lung diseases as well as the possible future of these discoveries in clinical applications. |
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| Keywords: | MicroARN Enfermedades pulmonares Tabaquismo Enfermedad pulmonar obstructiva cró nica Cá ncer de pulmó n Fibrosis pulmonar Lesió n pulmonar Asma |
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