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Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA)

Authors:	Masahisa Katsuno Fumiaki Tanaka Hiroaki Adachi Haruhiko Banno Keisuke Suzuki Hirohisa Watanabe Gen Sobue

Institution:	1. Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan;2. Institute for Advanced Research, Nagoya University, 464-8601, Japan

Abstract:

Keywords:	SBMA spinal and bulbar muscular atrophy AR androgen receptor HD Huntington's disease AF transcativation function CBP c-AMP response element binding protein-binding protein NI nuclear inclusion N/C amino- and carboxyl-terminal domains Hsp heat shock protein HAT histone acetyltransferase JNK c-Jun N-terminal kinase LHRH luteinizing hormone-releasing hormone 17-AAG 17-allylamino-17-demethoxygeldanamycin CHIP C terminus of heat shock cognate protein 70-interacting protein HDAC histone deacetylase ASC-J9 5-hydroxy-1 7-bis(3 4-dimethoxyphenyl)-1 4 6-heptatrien-3-one
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