果胶铋四联和三联疗法治疗幽门螺杆菌阳性十二指肠溃疡79例

目的：对比果胶铋四联（果胶铋、奥美拉唑、阿莫西林、甲硝唑）一周疗效和三联（果胶铋、阿莫西林、甲硝唑）两周疗法对确诊幽门螺杆菌阳性的十二指肠溃疡的疗效。方法：７９例随机分入四联疗法组（４０例）和三联疗法组（３９例）治疗。胃镜检查和组织活检于服药前及停药４周后进行。结果：四联疗法组溃疡愈合率为７８％，Ｈｐ根除率为９３％，不良反应发生率为３３％；而三联疗法组则分别为７２％，９０％和２８％，两组比较无显著

The effect of bismuth pectin quadruple and triple therapy on 79 cases of Helicobacter pylori positive duodenal ulcer

Objective:To compare the effect of one week bismuth pectin quadruple therapy(bismuth pectin,omeprazole,amoxicilln,and metronidazole)and two week triple therapy(bismuth pectin,amoxicillin,and metronidazole)on confirmed Helicobacter pylori (Hp)positive duodenal ulcer Methods:79 cases were randomly assigned to quadruple( n =40)or triple therapy groups( n =39) Endoscopy with biopsy histology was performed before and 4 weeks after the ceasation of treatment Results:The ulcer healing rate,Hp eradication rate,and incidence of mild adverse effects were 78%,93%,and 33%,respectively in quadruple therapy group,and 72%,90%,and 28% respectively in triple therapy group.There was no significant difference between the two groups.Conclusions:Both bismuth quadruple and triple therapy are effective in the treatment of Hp positive duodenal ulcer,but quadruple therapy has a shorter course and cheaper price.