伊班膦酸钠治疗恶性肿瘤骨转移疗效观察

目的:观察伊班膦酸钠治疗恶性肿瘤骨转移的疗效。方法:47例恶性肿瘤骨转移患者,应用伊班麟酸钠注射液(艾本,河北医科大学生物医学工程中心)4 mg加入生盐水500 m l中,静脉滴注≥2 h。4周1次,为1个周期,3个周期后评价疗效。结果:止痛效果总有效率为78.7%,体力状况改善总有效率为59.%,骨转移病灶疗效总有效率为57.4%,血钙变化有效率为80.0%,发热3例(6.4%),对症处理后1例(2.1%)出现流感症状,1例(2.1%)出现恶心、呕吐。结论:伊班膦酸钠止痛效果明显,起效快,患者生活质量明显提高,不良反应少,可以耐受。

Clinical observation of effect on malignant tumor osseous metastasis with ibandronate monosodium

Objective To observe the curative effect of ibandronate monosodium in treating malignant tumor osseous metastasis.Method All 47 cases,male 28,female 19,the age between 31~81 years.Ibandronate monosodium 4 mg added into physiological saline 500 ml,iv drop≥2 h,one time every 4 weeks,4 weeks as a cycle.The curative effect after 3 cycles was evaluated.Results Antiodontalgic effective rate was 78.7%,the fitness better rate was 59.6%,the effective rate treating osseous metastasis was 57.4%,the effective rate of blood calcium change was 80.0%.Adverse effests：Fever in 3 cases（6.4%）,1 case（2.1%） with flu symptom,1 case（2.1%） with gastrointestinal symptom after symptomatic treatment.Conclusion Ibandronate monosodium has better antiodontalgic effect and quick effect,can improve the quality of life,with less adverse effect,and good tolerance.