| Abstract: | An indirect electron-microscopic immunoperoxidase method, with pure rabbit antibodies against fibrillary protein of mouse amyloid, was used to study casein amyloidosis in mice. In the early stages of development of amyloidosis deposits of finely granular material appeared in the mouse myocardium. These deposits contained an antigen similar to the fibrillary antigen of amyloid, but were without its fibrillary ultrastructure. The results of this investigation point to the existence of an early nonfibrillary stage of amyloid formation.Laboratories of Electron Microscopy and General Pathological Anatomy, Institute of Human Morphology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 5, pp. 620–623, May, 1978. |
