| 白介素35在支气管哮喘中的作用机制 |
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| 引用本文： | 顾香,陈吉泉,李兵.白介素35在支气管哮喘中的作用机制[J].中华哮喘杂志（电子版）,2012,6(4):277-280. |
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| 作者姓名： | 顾香 陈吉泉 李兵 |
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| 作者单位： | 第二军医大学长征医院呼吸内科,上海,200003 |
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| 基金项目： | 上海市科学技术委员会资助项目(114119a3200) |
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| 摘 要： | 支气管哮喘（简称哮喘）是由多种细胞和细胞因子参与的慢性呼吸道炎症性疾病,发病机制可能与Th1/Th2细胞因子失衡、CD4＋CD25＋ T细胞（调节性T细胞,简称Tregs）及Th17/IL-17等异常有关。白介素35是一种新发现的细胞因子,其与Tregs及Th17/IL-17等免疫调节功能密切相关,通过多种途径参与哮喘的发病和调节,有望成为哮喘的治疗新靶点。本文对此相关研究作一综述
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| 关 键 词： | 白介素35 哮喘 发病机制 治疗 |
Role of interleukin-35 in the mechanism of bronchial asthma |
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| GU Xiang
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CHEN Ji-quan
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LI Bing.Role of interleukin-35 in the mechanism of bronchial asthma[J].Chinese Journal of Asthma(Electronic Version),2012,6(4):277-280. |
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| Authors: | GU Xiang CHEN Ji-quan LI Bing |
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| Institution: | .Department of Respiratory Medicine, Changzheng Hospital of Second Military Medical University, Shanghai 200003, China |
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| Abstract: | Bronchial asthma (asthma) is a chronic inflammatory airway disease involved in many cytokines, the mechanism may be related with the imbalance of Th1/Th2 cells or the abnormalities of CD4+CD25+T cells, Th17/IL-17 and so on. Interleukin-35 (IL-35) is a newly discovered cytokine, which is closely related to the immune function of Th17/IL-17 and Tregs. IL-35 may be involved in the pathogenesis of asthma, which is expected to become a new target for the treatment of asthma. This review describes the relative researches on IL-35. |
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| Keywords: | Interleukin-35 Asthma Pathogenesis Treatment |
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