四川成都地区脑出血发病的时间流行病学特点

目的 调查四川成都地区脑出血发病时间的季节差异,并找出其差异与该地区气候的相关性.方法 对四川成都市两城区内1 606例自发性脑出血患者临床流行病学资料进行统计分析.计算在整个时间段内各季节脑出血发病率的差异,并对气象因素与脑出血的发病关系进行探讨.结果 脑出血发病率在冬季最高(45.3,95%CI:39.1～51.5),夏季最低(24.1,95%CI:20.8～27.4);在不同的性别及年龄组(＜60岁组与≥60岁组)中,这一现象仍然存在.同时分析发现脑出血发病率与气候因子,如气温、气压、湿度、日照长度、风速等存在相关性.结论 自发性脑出血的发病率呈现一定的季节性差异,表现为冬季最高,夏季最低.高血压患者则表现出春季更易出现脑出血的趋势.这种季节差异性表现出与气候因子存在相关性,但具体作用机制需进一步探讨.

Abstract：

Objective The Objective of the present study is to determine whether the time of onset of the hemorrhage is associated with seasonality and to find out a possible relationship between its incidence in a determined area and meteorological variables.Methods Data were obtained from 10 medical centers in two of downtown districts of Chengdu, From November 1, 2005, to October 30, 2009, all consecutive adult patients with a spontaneous primary cerebral hemorrhage, were examined in this retrospective study.Seasonal variation was calculated for the whole period.The correlation between ICH incidence and meteorological variables was also investigated.Results Among the seasons, seasonal ICH incidence per 100,000 person-years was highest in winter (45.3,95% CI:39.1 ～51.5) and lowest in summer (24.1,95% CI:20.8～27.4) with significant difference.Winter incidence was highest in both men and women,and in subjects younger than 60 years as well as subjects 60 or older.The seasonal variation showed a high correlation with with temperature, air pressure , humidity, sunshine and wind.Conclusions The incidence of spontaneous cerebral hemorrhage showed a seasonal variation which induced a correlation with meteorological variables.ICH incidences appear to be highest in the cold winter among the population.Factors that explain this excess need further investigation.

The chronoepidemiology analysis of spontaneous intracerebral hemorrhage in Chengdu, Sichuan province

Objective The Objective of the present study is to determine whether the time of onset of the hemorrhage is associated with seasonality and to find out a possible relationship between its incidence in a determined area and meteorological variables.Methods Data were obtained from 10 medical centers in two of downtown districts of Chengdu, From November 1, 2005, to October 30, 2009, all consecutive adult patients with a spontaneous primary cerebral hemorrhage, were examined in this retrospective study.Seasonal variation was calculated for the whole period.The correlation between ICH incidence and meteorological variables was also investigated.Results Among the seasons, seasonal ICH incidence per 100,000 person-years was highest in winter (45.3,95% CI:39.1 ～51.5) and lowest in summer (24.1,95% CI:20.8～27.4) with significant difference.Winter incidence was highest in both men and women,and in subjects younger than 60 years as well as subjects 60 or older.The seasonal variation showed a high correlation with with temperature, air pressure , humidity, sunshine and wind.Conclusions The incidence of spontaneous cerebral hemorrhage showed a seasonal variation which induced a correlation with meteorological variables.ICH incidences appear to be highest in the cold winter among the population.Factors that explain this excess need further investigation.