| 阿尔采末病APP分泌酶及其靶向干预研究进展 |
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| 引用本文： | 李守业,朱妍,焦悦,李昌煜.阿尔采末病APP分泌酶及其靶向干预研究进展[J].中国药理学通报,2011,27(10):1349-1353. |
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| 作者姓名： | 李守业 朱妍 焦悦 李昌煜 |
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| 作者单位： | 浙江中医药大学,浙江,杭州,310053 |
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| 基金项目： | 浙江省科技计划资助项目，浙江省研究生创新科研资助项目，浙江省新苗人才计划资助项目 |
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| 摘 要： | α、β和γ3种分泌酶是淀粉样前体蛋白(APP)加工及代谢的关键酶,选择性地激活α分泌酶或抑制β和γ分泌酶,将有助于减少β-淀粉样蛋白(Aβ)的产生,并可能成为治疗AD的有效靶点。该文主要对APP 3种分泌酶活性表达的影响因素及其靶向干预研究的进展做一综述。
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| 关 键 词： | 阿尔采末病 β-淀粉样前体蛋白 分泌酶 靶向干预 激动剂 抑制剂 机制 |
Progress of APP secretase and targeted intervention on Alzheimer's disease |
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| LI Shou-ye,ZHU Yan,JIAO Yue,LI Chang-yu.Progress of APP secretase and targeted intervention on Alzheimer's disease[J].Chinese Pharmacological Bulletin,2011,27(10):1349-1353. |
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| Authors: | LI Shou-ye ZHU Yan JIAO Yue LI Chang-yu |
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| Institution: | LI Shou-ye,ZHU Yan,JIAO Yue,LI Chang-yu(Zhejiang Traditional Chinese Medicine University,Hangzhou 310053,China) |
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| Abstract: | α,β and γ secretases are three kinds of key enzymes in processing and metabolizing amyloid precursor protein(APP).Their selective activation of the α secretase or inhibition of β and γ secretase will help reduce the production of β-amyloid protein(Aβ),and may become one of the effective targets to treating AD.This paper aims to make a review on the research development of relevant factors influencing the activity and expression of 3 APP secretases and their targeted intervention in pharmaceutical studies. |
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| Keywords: | Alzheimer's disease amyloid precursor protein secretase targeted intervention agonist inhibitor mechanism |
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