中医优化方案治疗非酒精性脂肪性肝炎的临床研究

目的:探讨中医优化方案对非酒精性脂肪性肝炎(NASH)临床疗效。方法:共收集4个分中心的NASH患者202例,随机分为治疗组(101例)和对照组(101例),两组均在健康教育、饮食运动基础上进行药物治疗,治疗组使用中药饮片基本方颗粒剂+加减方颗粒剂,1剂/日。对照组使用多烯磷脂酰胆碱(易善复)胶囊,456 mg/次,3次/日。两组疗程均为3个月,随访3个月,观察治疗后ALT,肝/脾CT值,TG,BMI及症状体征的变化。结果:治疗组在降低ALT,TG,BMI,提高肝/脾CT值,改善症状方面均明显优于对照组(P<0.05)。结论:中医优化方案治疗NASH,疗效明显优于烯磷脂酰胆碱胶囊,可作为中医诊疗方案在临床进一步推广。

Clinical Trial of Chinese Medicine for the Treatment of Nonalcoholic Steatohepatitis

Objective: To investigate the effects of the Chinese medicine on non-alcoholic steatohepatitis (NASH). Method: Serum alanine aminotransferase(ALT), liver to spleen ratio triglyceride(TG), body mass index(BMI) and symptom signs of impact in patients were used for effecacy evaluation. In all, 202 patients with NASH were collected from four sub-centers and randomly divided into treatment group (101cases) and control group (101 cases). The patients of treatment group were treated for 3 months with a daily traditional Chinese medicine, and the patients of control group were treated for 3 months with polyene phosphatidylcholine capsules (Essentiale), 1 368 mg·d^-1. Each patient was advised regular aerobic exercise and dietary modification. Result: The treatment group was significantly better than control group on improved serum ALT levels, liver to spleen ratios, TG, body mass index BMI and symptoms(P<0. 05). Conclusion: The Chinese medicine for the treatment of NASH was better than Essentiale for improveing ALT levels, liver to spleen ratios, TG, BMI and symptoms. It can be promoted as a clinical treatment.