单味中药治疗糖尿病周围神经病变研究进展

中药治疗糖尿病周围神经病变疗效确切，具有多靶点、多层面、多途径等优势。单味中药治疗糖尿病周围神经病变研究取得一定的进展，本文主要细述不同中药及其有效成分治疗糖尿病周围神经病变（DPN），通过改善其不同的发病机制而取得一定的效果：水飞蓟素、槲皮素、牛蒡子、黄芩素、葛根素通过改善代谢因素进行干预治疗；灯盏花素、刺五加注射液、当归注射液、银杏叶注射液、丹参粉针、川芎嗪注射液、水蛭注射液治疗DPN主要通过改善其血管因素；桑白皮则通过影响神经因子的表达治疗DPN。同时，就该领域面临的问题进行分析及展望。

Research of single herbs in the treatment of Diabetic Peripheral Neuropathy

Although Diabetic peripheral neuropathy seriously affect the patient＇s quality of life, but its mec-hanism is still not completely clear. Compared to the modern medicine, traditional Chinese medicine treatment of diabetic peripheral neuropathy is more targets and multifaceted. In the research of Single taste of Chinese herbal medicine in treating diabetic peripheral neuropathy has achieved certain progress. According to the tathogenesis of DPN includes three aspects ： Metabolic factors （ includes Polyol pathway hyperactivity, Inositol reduce, Non-enzymatic Glycati-on end product formation ） ; Vascular disease factors （includes Abnormal fluid rheology, Vascular disorders, Vasoactive factors） ; The lack of neurotrophic factors, the author reviewed the research progress and problems to be solved in experimental studies and clinical studies of single taste of Chinese herbal and their extracts to treat diabetic peripheral neuropathy. The single taste of Chinese herbal , which Through the way of Inhibition of the polyol pathway hyperactivity of DPN intervention treatment, include Silymarin, Quercetin, Arctium, Baicalein, Puerarin etc. The way of Breviscapine, Ciwujia injection, Angelica sinensis injection, Ginkgo biloba injection to treat DPN is regulating abnormal blood theology. Some other single taste of Chinese herbal may stimulate the expression of neurotrophic factors increased to treat DPN. The lack of recognized disease and syndrome animal model, unified diagnostic criteria and unified clinical evaluation are still to be further studied.