氢溴酸西酞普兰片合并小剂量米氮平片治疗抑郁症的临床研究

目的比较氢溴酸西酞普兰片合并小剂量米氮平片与单用氢溴酸西酞普兰片治疗抑郁症的疗效及不良反应。方法将符合标准的88例抑郁症患者分为两组,治疗组给予氢溴酸西酞普兰片合并米氮平片治疗（n=45）,对照组予氢溴酸西酞普兰治疗（n=43）,疗程6周。用汉密尔顿抑郁量表（HAMD）在治疗前及治疗1、2、4、6周末评定疗效,用副反应量表（TESS）评定不良反应。结果两组总体疗效有显著差异性（P〈0.05）：治疗组对抑郁症起效较快,临床治愈率更高,副作用没有明显增加。结论氢溴酸西酞普兰合并小剂量米氮平片治疗抑郁症值得临床推广。

A clinical study of combined Citalopram Hydrobromide and small dose Mirtazapine tablets in the treatment of depression

Objective To compare the curative effect of treating and adverse reaction in the treatment for ciepresslon between the group take orally Citalopram Hydrobromide tablets with small dose Mirtazapine tablets and the group only take orally Citalopram Hydrobromide tablets. Methods Eighty-eight depression patients were divided into two groups in random, treatment group take orally Citalopram Hydrobromide tablets with small dose Mirtazapine tablets（n=45）, control group only take orally Citalopram Hydrobromide tablets（n=43）. Course of treatment was six weeks. Adopted Hamilton depression rating scale（HAMD） estimating the curative effect of treating before treatment and 1, 2, 4, 6 weeks for all patients. And adopted Treatment Emergent Symptom Scale（TESS） evaluating adverse reactions for all patients. Restflts The overall efficacy was significant difference for two groups： the treatment group got effective fast, clinical cure rate was higher, side effects was not significantly increased. Conclusion Takeing orally Citalopram Hydrobromide tablets with small dose Mirtazapine tablets treat depression is worth clinical promoting.