| 亚硒酸钠对大鼠肾小球系膜细胞表达环氧化酶2的影响 |
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| 引用本文： | 魏倩萍,邓华聪,赵劼. 亚硒酸钠对大鼠肾小球系膜细胞表达环氧化酶2的影响[J]. 中华内分泌代谢杂志, 2006, 22(4): 376-377 |
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| 作者姓名： | 魏倩萍 邓华聪 赵劼 |
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| 作者单位： | 1. 400016,重庆医科大学附属第一医院内分泌科
2. 重庆医科大学超声工程研究所 |
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| 摘 要： | 分别以高葡萄糖、高胰岛素、过氧化氢和糖基化终产物孵育大鼠肾小球系膜细胞（RGMC），均可使RGMC环氧化酶（COX）-2mRNA和蛋白表达增加（均P〈0．01）；亚硒酸钠预处理后可抑制上述4种因素诱导的COX-2 mRNA和蛋白表达。亚硒酸钠可能通过抑制COX-2在RGMC的表达，从而在防治糖尿病肾病发生发展过程中发挥重要作用。
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| 关 键 词： | 亚硒酸钠 环氧化酶2 糖尿病肾病 大鼠肾小球系膜细胞 |
| 收稿时间： | 2005-03-29 |
| 修稿时间： | 2005-03-29 |
A role of sodium selenite in regulating expression of cyclooxygenase-2 in rat mesangial cells |
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| WEI Qian-ping,DENG Hua-cong,ZHAO Jie. A role of sodium selenite in regulating expression of cyclooxygenase-2 in rat mesangial cells[J]. Chinese Journal of Endocrinology and Metabolism, 2006, 22(4): 376-377 |
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| Authors: | WEI Qian-ping DENG Hua-cong ZHAO Jie |
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| Affiliation: | Department of Endocrinolgy, The First Hospital Affiliated to Chongqing Medical University, Chongqing 400016 |
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| Abstract: | The expression of cyclooxygenase-2 (COX-2) mRNA and protein was significantly increased in rat glomerular mesangial cells (RCMC) treated separately with high glucose, high insulin, H2 O2 and advanced glycosylation end products. The expressions of COX-2 mRNA and protein in RCMC induced by above 4 factors were distinctly inhibited by sodium selenite, suggesting that sodium selenite might play a significant role in the prevention of diabetic nephropathy via this mechanism. |
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| Keywords: | Sodium selenite Cyclooxygenase-2 Diabetic nephropathies Mesangial cells |
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