肝病患者庚型肝炎病毒感染的临床分析

目的探讨肝病患者庚型肝炎病毒感染情况及致病性。方法应用RT-PCR方法检测312例肝病患者HGV-RNA及甲～戊型肝炎血清学标志。以HGV-RNA阳性为HGV感染判断标准,分析各型肝病患者HGV感染情况。结果312例患者HGV-RNA阳性64例,阳性率为20.51%;单纯HGV感染12例,阳性率为3.85%。结论急性肝炎,乙、丙型慢性肝炎,肝硬化,重型肝炎患者均可检出HGV-RNA。HGV多与乙、丙型肝炎病毒混合或重叠感染,亦可单纯感染引起肝脏炎症,说明HGV可能是肝病患者的致病因素之一。

The clinical study of hepatitis G virus infection among patients with liver diseases

Objective To explore the hepatitis G virus (HGV) infection and pathogenicity among patients with liver diseases. Methods HGV RNA was detected by RT PCR among 312 patients with liver diseases.The serum markers from hepatitis A to hepatitis E were also detected. The positivity of HGV RNA was taken as diagnosis criteria for HGV infection in different types of liver diseases. Result Total HGV RNA positive were found in 64 of 312 patients with liver disease. Simple HGV infection were found in 12 cases of all patients. The detectable rate of HGV RNA were 20.51%(64/312) and 3.85%(12/312) respectively. Conclusion HGV RNA could be detected in acute hepatitis, chronic hepatitis, liver cirrhosis, fulminant hepatitis and cholestatic hepatitis.Simple HGV RNA can cause hepatitis only. HGV may be a responsible agent for hepatitis.