| 乳头状甲状腺癌与BRAF基因相关性的研究进展 |
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| 引用本文： | 石臣磊 综述 秦华东 审校. 乳头状甲状腺癌与BRAF基因相关性的研究进展[J]. 中国普通外科杂志, 2014, 23(5): 675-679 |
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| 作者姓名： | 石臣磊 综述 秦华东 审校 |
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| 作者单位： | （哈尔滨医科大学附属第二临床医院 普外四科，黑龙江 哈尔滨 150086 ） |
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| 基金项目： | 黑龙江省自然科学基金资助项目(D201228)；哈尔滨医科大学附属二院青年基金资助项目（QN2012-07）。 |
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| 摘 要： | 鼠类肉瘤滤过性毒菌致癌同源体B1（BRAF）基因突变是甲状腺癌中最常见的遗传学事件，在乳头状甲状腺癌（PTC）中发生率最高。目前研究证明BRAF V600E基因突变与PTC的发生、发展密切相关。并且作为PTC高效的风险预测分子标记物，能够帮助外科医生制定更为个体化的治疗方案。笔者就PTC与BRAF基因相关性的最新研究进展进行综述。
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| 关 键 词： | 甲状腺肿瘤；癌，乳头状；BRAF基因；综述文献 |
| 收稿时间： | 2013-09-05 |
| 修稿时间： | 2013-10-24 |
Relationship between papillary thyroid carcinoma and BRAF gene: recent progress |
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| SHI Chenlei,QIN Huadong. Relationship between papillary thyroid carcinoma and BRAF gene: recent progress[J]. Chinese Journal of General Surgery, 2014, 23(5): 675-679 |
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| Authors: | SHI Chenlei QIN Huadong |
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| Affiliation: | (The Fourth Department of General Surgery, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China) |
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| Abstract: | Mutation in V-raf murine sarcoma viral oncogene homolog B1 (BRAF) gene is the most common genetic event in thyroid cancer, particularly in papillary thyroid cancer (PTC). Recent investigations indicate that BRAF V600E gene mutation is closely related to the occurrence and development of PTC. Further, as an effective risk-predicting molecular marker for PTC, it can help surgeons make personalized treatment plan for PTC patients. Here, the authors present the recent progress involving the relationship between PTC and BRAF gene. |
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| Keywords: | Thyroid Neoplasms Carcinoma, Papillary BRAF Gene Review |
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