纳米羟基磷灰石/聚磷酸钙纤维/聚乳酸骨组织工程复合支架的特性

背景:近年来国内外在骨与软骨组织支架复合材料方面进行了广泛的研究,取得了积极的成果,但仍存在许多问题.目的:观察纳米羟基磷灰石/聚磷酸钙纤维/聚乳酸(HAP/CPP/PLLA)骨组织工程支架复合材料的特性.方法:采用溶媒浇铸、粒子滤取技术与气体发泡相结合的方法制备出纳米HAP/CPP/PLLA 骨组织工程支架复合材料,测试该支架复合材料的物理力学性能,并用扫描电子显微镜对其微观结构进行观察.结果与结论:结果表明,纳米HAP/CPP/PLLA 支架复合材料具有三维、连通、微孔网状结构,并具有较高的孔隙率和较好的压缩模量,是理想的骨组织工程支架材料.

Fabrication and properties of nanometer hydroxyapatite/calcium polyphosphate/poly(L-lactic acid) composite scaffold for bone tissue engineering

BACKGROUND:Studies have achieved great progresses in compound materials for bone and cartilage tissue scaffolds.However,there are still some problems.OBJECTIVE:To observe the fabrication and properties of nanometer hydroxyapatite/calcium polyphosphate/poly(L-lactic acid)(nanometer HAP/CPP/PLLA) composite scaffold for bone tissue engineering.METHODS:Nanometer HAP/CPP/PLLA composite scaffold was prepared by solvent casting,particulate leaching combined with gas foaming.The properties of physical mechanics were tested.RESULTS AND CONCLUSION:The experimental results showed that the composite scaffold had high porosity and compressive modulus as well as the three-dimensional,connectivity network microstructures.Therefore,this composite may be one of scaffold materials for bone tissue engineering with potentially broad applicability.