| 甘草次酸醇质体的制备研究 |
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| 引用本文： | 韩腾飞,闫菁华,豆婧婧,惠先,徐坤,陈贵,郝保华.甘草次酸醇质体的制备研究[J].西北药学杂志,2012,27(1):64-66. |
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| 作者姓名： | 韩腾飞 闫菁华 豆婧婧 惠先 徐坤 陈贵 郝保华 |
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| 作者单位： | 西北大学生命科学学院中药系,西安,710069 |
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| 基金项目： | 国家重大新药创制科技重大专项(2009ZX09502-019) |
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| 摘 要： | 目的优选甘草次酸(GA)醇质体的最佳制备工艺。方法乙醇注入法制备GA醇质体,以包封率为评价指标,采用正交设计实验确定GA醇质体的最佳制备工艺。结果确定GA醇质体最佳制备工艺为:含GA0.5g的100mLGA醇质体中无水乙醇投入35mL,大豆磷脂3.0g,胆固醇0.2g。所制得的醇质体平均包封率为70.6%。结论以乙醇注入法制备的GA醇质体,包封率高、稳定。
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| 关 键 词： | 甘草次酸 醇质体 包封率 |
Study on the preparation technique of glycyrrhetinic acid ethosomes |
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| HAN Tengfei,YAN Jinghua,DOU Jingjing,HUI Xian,XU Kun,CHEN Gui,HAO Baohua.Study on the preparation technique of glycyrrhetinic acid ethosomes[J].Northwest Pharmaceutical Journal,2012,27(1):64-66. |
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| Authors: | HAN Tengfei YAN Jinghua DOU Jingjing HUI Xian XU Kun CHEN Gui HAO Baohua |
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| Institution: | (College of Life Science,Northwest University,Xi’an 710069,China) |
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| Abstract: | Objective To optimize the best preparation method of glycyrrhetinic acid(GA) ethosomes.Methods GA ethosomes were prepared by ethanol injection method.A reasonable criterion of accurate evaluation was established so that the best preparation conditions were determined.Results The optimized preparation conditions for glycyrrhetinic acid ethosomes were obtained as follows:the 100 mL glycyrrhetinic acid ethosomes containing 0.5 g GA with absolute alcohol 35 mL,soybean phospholipid quantity 3.0 g,cholesterol quantity 0.2 g.The average encapsulation efficiency was 70.6%.Conclusion The selected formulation and preparation method of glycyrrhetinic acid ethosomes are rational and stable. |
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| Keywords: | glycyrrhetinic acid(GA) ethosome encapsulation efficiency |
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