静脉输注骨髓间充质干细胞的归巢路径

背景:间充质干细胞被认为是最有希望用于治疗多种疾病的一种非造血组织的多能干细胞,但是其靶向组织器官归巢率偏低,影响了其作为干细胞疗法的效果。目的:通过对国内外相关文献的综合分析,探讨静脉输注骨髓间充质干细胞的归巢现象。方法:利用计算机检索清华同方数据库、万方数据库、Pubmed数据库,检索英文关键词为"Bone marrow mesenchymal stemcells,homing",中文关键词为"骨髓间充质干细胞,归巢",主要筛选出近10年内最具代表性的文献资料。经查阅、整理出33篇可支持本综述的文献。结果与结论:研究发现,静脉输注的骨髓间充质干细胞与血管壁接触并穿过内皮细胞从而归巢至多个脏器,特别是损伤、炎症及肿瘤部位。文章从静脉输注骨髓间充质干细胞的归巢特点,输注回输骨髓间充质干细胞迁移与归巢的可能机制等方面进行了相关论述。归巢的机制与参与调控的信号分子及其受体,如趋化因子、生长因子和黏附分子等有关。

Intravenous bone marrow mesenchymal stem cells homing pathways

BACKGROUND: Mesenchymal stem cells (MSCs), as non-hematopoietic multipotent stem cells, are considered as the most promising stem cells for the treatment of a variety of diseases. But their low rate of homing to target tissues and organs limit the therapeutic efficacy when they are used in stem cell therapy. OBJECTIVE: To investigate intravenous bone marrow MSCs homing phenomena and mechanisms based on analysis of related literatures at home or abroad.METHODS: A computer-based online search of CNKI database, Wanfang database and PubMed database was performed with Key words "Bone marrow mesenchymal stem cells, homing" in Chinese and in English, respectively. And the articles were mainly selected to be the most representative literatures during the last 10 years. Totally 33 literatures were included according to inspection and sorting.RESULTS AND CONCLUSION: Many studies showed that intravenous bone marrow MSCs interacted with the vessel wall and migrated across the endothelium, homing to many tissues and organs, especially damaged tissue, inflammation and tumor. This article was discussed from the intravenous MSCs homing phenomena and mechanisms. We describe the regulatory signaling molecules and receptors involved, such as chemotatic factor and growth factor, and adhesion molecules.