纳米载银磷酸锆抗菌聚氨酯的抗菌性能

背景:聚氨酯材料具有优异的物理和化学性能,良好的生物相容性和抗凝血性能,且易加工成形,但聚氨酯制造的人工器官容易受到细菌等微生物的入侵。目的:观察纳米载银无机抗菌剂对聚氨酯抗菌性能的影响。方法:将纳米载银无机抗菌剂RHA-2,按0%(空白对照组),0.5%,1%,1.5%,2%,2.5%,5%比例添加到聚氨酯中。采用薄膜密着法检测抗菌聚氨酯对金黄色葡萄球菌、大肠杆菌的抑菌作用,并分析比较抗菌剂添加比例与聚氨酯抗菌性能的相关性。结果与结论:添加纳米载银无机抗菌剂的聚氨酯对金黄色葡萄球菌、大肠杆菌具有良好的抑菌作用。抗菌剂添加比例0.5%~5%组对金黄色葡萄球菌的抑菌率分别为80.23%,91.32%,95.23%,99.19%,99.87%,99.93%,对大肠杆菌的抑菌率分别为76.70%,86.96%,92.92%,95.43%,99.34%,99.87%,显示抗菌性能随抗菌剂添加比例的上升而明显提高。表明纳米载银无机抗菌剂的添加赋予了聚氨酯优异的抗菌性能,且从抗菌角度出发,推荐纳米载银无机抗菌剂在聚氨酯中的添加比例不应低于1.5%。

Antibacterial performance of nano-silver-zirconium phosphate antibacterial polyurethane

BACKGROUND: Polyurethane material has excellent physical and chemical performances, good biocompatibility and anti-clotting properties, and is easy to shape. However, artificial organs manufactured using the polyurethane are vulnerable to the invasion of bacteria and other microorganisms. OBJECTIVE: To explore the effects of nano-silver base inorganic antimicrobial agent on the antibacterial performance of polyurethane. METHODS: The nano-silver base inorganic antimicrobial agent RHA-2 was added to polyurethane by the mass fractions of 0% (blank control), 0.5%, 1%, 1.5%, 2%, 2.5% and 5%, respectively. Antimicrobial properties of the polyurethane materials against Staphylococcus aureus and Escherichia coli were assayed using the pellicle sticking method. RESULTS AND CONCLUSION: The polyurethane added with nano-silver base inorganic antimicrobial agents had a good antibacterial effect on Staphylococcus aureus and Escherichia coli. The inhibitory rate against Staphylococcus aureus in the groups containing 0.5%-5% antimicrobial agents were 80.23%, 91.32%, 95.23%, 99.19%, 99.87% and 99.93%, respectively; the inhibitory rate against Escherichia coli in the corresponding groups were 76.70%, 86.96%, 92.92%, 95.43%, 99.34% and 99.87%, respectively. The antimicrobial properties of polyurethane increased significantly with the increasing proportions of the antibacterial agents. These results indicate that nano-silver base inorganic antimicrobial agents can endow the polyurethanes an excellent antibacterial property. From the antimicrobial perspective, the recommended adding proportion of the nano-silver base inorganic antimicrobial agents in the polyurethane is no less than 1.5%.