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| 盐酸利多卡因凝胶剂的制备工艺研究 | |
| 引用本文： | 张珩,施春阳,王兰,丁倩.盐酸利多卡因凝胶剂的制备工艺研究[J].西北药学杂志,2012,27(1):68-70. |
| 作者姓名： | 张珩 施春阳 王兰 丁倩 |
| 作者单位： | 1. 陕西省妇幼保健院药械科,西安,710003 2. 陕西科技大学生命科学与工程学院,西安,710021 3. 西安利君制药有限责任公司,西安,710077 |
| 摘 要： | 目的制备并优化盐酸利多卡因凝胶剂。方法以盐酸利多卡因为主药,卡波姆-941、PEG-400和azone等为基质,制备凝胶剂;以离体皮肤渗透速率为指标,采用正交实验优化处方。结果最优处方为:盐酸利多卡因8.8g,卡波姆-941 3.5g,1,2-丙二醇62.5g;azone 6.5g,PEG-400 13.0g,蒸馏水加至200g。该凝胶剂的盐酸利多卡因离体皮肤渗透速率为744.45μg.h-1.cm-2,稳定性好。结论制备的盐酸利多卡因凝胶剂符合药典要求,质量稳定。 |
| 关 键 词： | 盐酸利多卡因 凝胶剂 处方优化 |
Study on preparation of Lidocaine Hydrochloride Gelatin |
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| ZHANG Heng,SHI Chunyang,WANG Lan,DING Qian.Study on preparation of Lidocaine Hydrochloride Gelatin[J].Northwest Pharmaceutical Journal,2012,27(1):68-70. | |
| Authors: | ZHANG Heng SHI Chunyang WANG Lan DING Qian |
| Institution: | 1.Shaanxi Women and Children Hospital and Health Institute,Xi’an 710003,China;2.School of Life Science and Engineering,Shaanxi University of Science &Technology,Xi’an 710021,China;3.Xi’an Lijun Pharmaceutical Co.Ltd.,Xi’an 710077,China) |
| Abstract: | Objective To optimize the preparation procedure of Lidocaine Hydrochloride Gelatin.Method Gelatin was prepared by using lidocaine hydrochloride as the main component and carbomer-941,PEG-400 and azone as the matrix.The permeation rate of skin in vitro was used as an indicator in orthogonal design tests.Results The optimized conditions were as follows:lidocaine hydrochloride 8.8 g,carbomer-941 3.5 g,1,2-propanediol 62.5 g,azone 6.5 g,PEG-400 13.0 g,distilled water to 200 g.The gel permeation rate of lidocaine was 744.45 μg·h-1·cm-2.Conclusion The proposed procedure could obtain Lidocaine Hydrochloride Gelatin which can attain the requirement of Chinese Pharmacopoeia. |
| Keywords: | lidocaine hydrochloride Gelatin formulation optimization |
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