HPLC determination of azapropazone in human plasma

Determination of Azapropazone in Human Plasma by HPLC A HPLC method is described to determine azapropazone in human plasma. Azapropazone is extracted from acidified plasma samples (pH 4) with dichloroethane and reextracted into an alkaline methanol solution. Concentrations down to 0.1 μg per milliliter plasma can be determined. The procedure is suitable for pharmacokinetic routine analyses.