| RELATIONSHIP BETWEEN THE CLINICAL USE OF ANTIBIOTIC AND PRODUCTION OF ESBLS |
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| 引用本文： | Liu Wenen,Tang Yin,Wang Lange,Tan Deming Xiangya Hospital,Central South University,Changsha 410008. RELATIONSHIP BETWEEN THE CLINICAL USE OF ANTIBIOTIC AND PRODUCTION OF ESBLS[J]. 中国现代医学杂志, 2003, 13(8): 18-20 |
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| 作者姓名： | Liu Wenen Tang Yin Wang Lange Tan Deming Xiangya Hospital Central South University Changsha 410008 |
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| 作者单位： | Liu Wenen，Tang Yin，Wang Lange，Tan Deming Xiangya Hospital，Central South University，Changsha 410008 |
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| 基金项目： | ThisworkwassupportedbygrantsfromtheWeiShengTingofHunanProvince (NO .0 0 0 3 0 ) |
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| 摘 要： | Extended -spectrum β -lactamases(ESBLs)aremainlyproducedbymembersofthefamilyEnter obacteriaceaewhichcanhydrolyzeβ -lactamantibi oticsincludingthethird - generationcephalosporinandaztreonam ,theESBLs- producingbacillishowedmedian -highresistancetoceftazidimeandaztreonamparticularly[1] .NowadaystheprevalenceofESBLs -producingstrainshavebeenreportedinmanyareasaroundtheworld[2 ] .ButthereisfewinformationabouttherelationshipbetweentheuseofantibioticandtheproductionofESBLs .Weperformedastud…
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| 关 键 词： | 抗生素 ESBLs 细菌 临床应用 |
Relationship between the Clinical Use of Antibiotic and Production of ESBLS |
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| Liu Wenen,Tang Yin,Wang Lange,Tan Deming. Relationship between the Clinical Use of Antibiotic and Production of ESBLS[J]. China Journal of Modern Medicine, 2003, 13(8): 18-20 |
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| Authors: | Liu Wenen Tang Yin Wang Lange Tan Deming |
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| Abstract: | Objective:To determine the relationship between the application of antibiotic and the production of extended spectrum β-lactamases (ESBLs).Methods:ESBLs were detected by the double disc diffusion method among 161 gram-negative bacilli isolated from clinical specimens.The use of antibiotic in the patients was investigated before ESBLs were detected. Results:The rate of ESBLs-producing strains was 35.4% (57/161). In the patients with ESBLs-producing strains, the utilization rates of antibiotic and the third-generation cephalosprin were 96.4% (55/57) and 42.1% (24/57) respectively, which were significantly higher than those without ESBLs-producing strains [80.6% (84/104) and 16.3% (17/104), respectively].There were significant differences (P＜0.05 and P＜0.005,respectively) between the two groups of patients.The duration of the third-generation cephalosprins therapy was significantly longer in the patients with ESBLs-producing strains [(7.5 ± 5.4)d] than those without ESBLs-producing strains [(2.7±2.6)d,P＜0.05].Conclusion:The application of antibiotic, especially the third-generation cephalosprins, is the risk factor for the production of ESBLs. |
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| Keywords: | Antibiotic Bacteria |
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