| 西藏藏族人群血管紧张素转换酶基因多态性分布 |
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| 引用本文： | 高静,任甫,席焕久,文普帅,黄克强,温有锋. 西藏藏族人群血管紧张素转换酶基因多态性分布[J]. 解剖学杂志, 2007, 30(2): 227-229 |
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| 作者姓名： | 高静 任甫 席焕久 文普帅 黄克强 温有锋 |
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| 作者单位： | 1. 辽宁医学院人类学研究所,锦州,121000
2. 辽宁医学院附属二院,锦州,121000 |
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| 基金项目： | 国家自然科学基金(30570977)，辽宁省教育厅基金(2004C038)，教育部科学技术研究项目(地方高校)基金(206031) |
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| 摘 要： | 目的:探讨西藏拉萨、那曲地区藏族健康人群血管紧张素转换酶(ACE)基因第16内含子287bpAlu顺序插入/缺失(I/D)多态性分布。方法:采用聚合酶链反应(PCR)方法检测ACE基因型。结果:76例拉萨藏族人ACE基因型频率分别为Ⅱ=0．395,ID=0．316,DD=0．289,等位基因频率分别为Ⅰ=0．553,D=0．447。81例那曲藏族人ACE基因型频率分别为Ⅱ=0．346,ID=0．444,DD=0．210,等位基因频率分别为Ⅰ=0．568,D=0．432。结论:拉萨、那曲地区藏族人ACE基因型及等位基因频率分布无显著差异;西藏藏族与英国白人和美国黑人相比基因型及等位基因频率均存在显著性差异,但与韩国人及日本人相似。
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| 关 键 词： | 血管紧张素转换酶 基因多态性 藏族 高原适应 |
| 修稿时间： | 2006-09-112006-11-27 |
Distribution of angiotensin converting enzyme gene polymorphism in Tibetan nationality |
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| Gao Jing,Ren Fu,Xi Huanjiu,Wen Pushuai,Huang Keqiang,Wen Youfeng. Distribution of angiotensin converting enzyme gene polymorphism in Tibetan nationality[J]. Chinese Journal of Anatomy, 2007, 30(2): 227-229 |
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| Authors: | Gao Jing Ren Fu Xi Huanjiu Wen Pushuai Huang Keqiang Wen Youfeng |
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| Affiliation: | 1 Institute of Anthropology ; 2 Second Affiliated Hospital, Liaoning Medical College, Jinzhou 121000, China |
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| Abstract: | Objective:To investigate the distribution of 287bp fragment insertion/deletion(I/D) polymorphism at intron 16 of angiotensin converting enzyme(ACE) gene of healthy Tibetan nationality in Lhasa and Naqu.Methods:Polymer- ase chain reaction (PCR) was used to determine the ACE genotype.Results:The frequencies of ACE genotypes of 76 Lhasa Tibetan were II=0.395,ID=0.316,DD=0.289;the allele frequencies were I=0.553,D=0.447.The fre- quencies of ACE genotypes of 81 Naqu Tibetan were II=0.346,ID=0.444,DD=0.21;and the allele frequencies were I=0.568,D=0.432.Conclusion:There is no significant difference between Lhasa and Naqu Tibetan in the fre- quency distribution of ACE genotypes and alleles;in Tibetan from Tibet,the distribution of ACE gene I/D polymor- phism is significantly different from White Britisher and Black American,but similar to Korean and Japanese. |
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| Keywords: | angiotensin converting enzyme gene polymorphism Tibetan altitude adaptation |
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