高血压与老年人认知功能障碍的相关性

目的探讨老年人高血压与认知功能障碍的相关性方法选择2011年1月~2013年12月在我院就诊的原发性老年高血压患者（病程5年以上）326例作为观察组，并选取老年健康人群320例作对照。对选择对象采用中文版简易智能量表评定认知功能，对两组人群采用对照分析的方法。结果（1）高血压组患者的简易智能量表得分均明显低于正常对照组（P<0.01）；高血压组患者的轻度认知功能障碍比例明显高于正常对照组（P<0.01）；（2）随着血压分级的升高，简易智能量表得分呈下降趋势，轻度认知功能障碍的患病率也随之增高，差异均有显著性意义（P<0.01）；（3）轻度认知功能障碍患病率与高血压分级、LDL-c、OGTT2 h血糖呈显著正相关。结论（1）高血压疾病与老年人认知障碍的发生关系密切，并且高血压程度越高，认知障碍越严重；（2）老年人认知障碍与高血压分级、低密度脂蛋白、OGTT2 h血糖等危险因素相关。

Correlation between hypertension and cognitive impairment in elderly people

Objective To explore the relation of essential hypertension and cognitive impairment in elderly people. Methods A total of 326 elderly patients with essential hypertention (with at least 5 years of history) from January 2011 to December 2013 were taken as observation group,and 300 healthy elderly people as the control group. The mini-mental state examination (MMSE) score were used to assessed cognitive function. Results (1)The MMSE score of hypertention patients was significantly lower than that of control group (P<0.01). The prevalence of mild cognitive impairment(MCI)of hypertention patients was higher than that of control group (P<0.01). (2)MMSE score decreased with increasing blood level (P<0.01). Increasing prevalence of MCI was found in the subjects with high grade of hypertension (P<0.01). (3)The prevalence of MCI had a significant negative correlation with the grade of hypertension,LDL level and 2-hr plasma glucose. Conclusion (1)There is a close relation between hypertention and cognitive impairment in elderly pe ople.Seriousness of cognitive impairment is associated with high blood pressure. (2)The cognitive impairment in elderly people is associated with the grade of hypertention,LDL level and 2-hr plasma glucose.