| 血管内皮生长因子受体-1和 COX-2在胃癌中的表达及临床意义 |
| |
| 引用本文： | 张君红,林瑶光,韦敏怡,陆云飞.血管内皮生长因子受体-1和 COX-2在胃癌中的表达及临床意义[J].重庆医学,2010,39(8). |
| |
| 作者姓名： | 张君红 林瑶光 韦敏怡 陆云飞 |
| |
| 作者单位： | 广西医科大学第一附属医院老年消化内科,南宁,530021;广西医科大学病理学教研室,南宁,530021;广西医科大学第一附属医院胃肠腺体外科,南宁,530021 |
| |
| 摘 要： | 目的研究血管内皮生长因子受体-1(Flt-1)和环氧合酶-2(COX-2)在胃癌中的表达及其临床意义。方法选择80例手术切除的胃癌标本为观察组,30例胃癌旁、40例慢性非萎缩性胃炎组织为对照组,应用免疫组织化学方法检测组织中Flt-1及COX-2的蛋白表达。结果Flt-1及COX-2在胃癌中的表达率均为52.5%,在癌旁及对照组的阳性率分别为13.3%、0%、7.5%、0%,差异均有统计学意义(P0.01),二者的表达与胃癌的TNM分期及浸润呈正相关,它们的阳性表达强度与肿瘤淋巴及血道转移呈正相关(P0.05),与肿瘤大小、分化程度无关(P0.05)。Flt-1、COX-2在胃癌组织中表达呈正相关(γ=0.608,P=0.000)。结论Flt-1、COX-2参与胃癌的发生、发展,二者在胃癌的发生、浸润转移中可能存在相互协同作用,联合检测Flt-1、COX-2可作为胃癌浸润、转移的重要判定指标。
|
| 关 键 词： | 胃肿瘤 血管内皮生长因子受体-1 环氧合酶-2 |
Expression and clinical significance of Flt-1 and COX-2 in gastric cancer |
| |
| ZHANG Jun-hong,LIN Yao-guang,WEI Min-yi,et al..Expression and clinical significance of Flt-1 and COX-2 in gastric cancer[J].Chongqing Medical Journal,2010,39(8). |
| |
| Authors: | ZHANG Jun-hong LIN Yao-guang WEI Min-yi |
| |
| Institution: | ZHANG Jun-hong1,LIN Yao-guang1,WEI Min-yi2,et al.(1.Department of Gerontism Gastroenterology,2.Pathological Department,3.Department of Gastrointestinal Surgery,First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi Zhuang Autonomous Region,530021,China) |
| |
| Abstract: | Objective To investigate the expression and clinical significance of vascular growth factor receptor-1(Flt-1) and COX-2 in gastric cancer.Methods Tissue section from 80 gastric cancer(GC),30 tissue section from side gastric cancer,40 chronic non-atrophy gastritis tissue were examined by using immunohistochemistry for the expression of Flt-1 and COX-2.Results The positivity rates of Flt-1 and COX-2 were both 52.5%,which were significantly higher than that in patients with side gastric cancer and chronic non-... |
| |
| Keywords: | gastric neoplasms Flt-1 COX-2 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
