Multiple sclerosis,interferon beta and clinical thyroid dysfunction |
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Authors: | Kreisler A,de Seze J,Stojkovic T,Delisse B,Combelles M,Vérier A,Hautecoeur P,Vermersch P Groupe septentrional d'étude et de recherche sur la Sclérose en Plaques |
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Affiliation: | Department of Neurology, Lille University Hospital, France. |
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Abstract: | The objective of this study was to investigate frequency and presentation of clinical thyroid dysfunction in patients treated with interferon beta (IFN-beta). We have collected the cases of clinical thyroid dysfunction in 700 consecutive patients receiving IFN-beta for multiple sclerosis (MS). Five patients (four women, one man) treated with IFN-beta1b developed hyperthyroidism. Three of them have secondary progressive MS, and two have relapsing-remitting MS. It was necessary to stop IFN-beta in three cases; these patients still require carbimazole after several months. In the two other cases, hyperthyroidism disappeared spontaneously. Two patients (one man and one woman) treated with IFN-beta1a developed hypothyroidism. One of them required l-thyroxine. Lastly, an increased thyroid volume without modification of thyroid hormones plasma levels was discovered in a patient receiving IFN-beta1a. Among patients treated with IFN-beta, clinical thyroid dysfunction is much rarer than laboratory thyroid dysfunction. However, this side-effect is sometimes severe. |
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Keywords: | multiple sclerosis interferon β side-effects thyroid dysfunction |
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