| 急性低压缺氧对血清一氧化氮和内皮素的影响 |
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| 引用本文： | 王昊,张慧,沈俊.急性低压缺氧对血清一氧化氮和内皮素的影响[J].海军医学杂志,2002,23(2):110-111. |
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| 作者姓名： | 王昊 张慧 沈俊 |
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| 作者单位： | 海军医学研究所,上海,200433 |
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| 摘 要： | 目的：探讨急性低压缺氧时一氧化氮（NO）、内皮素（ET）的变化及其相互关系。方法：36只健康雄性SD大鼠，随机分为对照组、5000m低压缺氧组、8000m低压缺氧组。采用硝酸还原酶法测定血清中NO含量、放射免疫法测定ET含量。结果：5000m、8000m急性低压缺氧组与对照组比较，血清NO含量显著降低（P＜0．05）；血清ET含量显著升高（P＜0．05或P＜0．01）；5000m组与8000m相比，NO、ET含量均无显著性差异（P＞0．05）。结论：缺氧后机体发生病理改变与NO合成下降、ET合成增加导致功能失衡有关。
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| 关 键 词： | 一氧化氮 内皮素 急性低压缺氧 |
| 文章编号： | 1009-0754(2002)02-0110-02 |
| 修稿时间： | 2001年7月28日 |
The Effect of Acute Hypobaric Hypoxia on NO and ET in Blood Serum |
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| WANG Hao,ZHANG Hui,SHEN Jun.The Effect of Acute Hypobaric Hypoxia on NO and ET in Blood Serum[J].Journal of Navy Medicine,2002,23(2):110-111. |
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| Authors: | WANG Hao ZHANG Hui SHEN Jun |
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| Abstract: | Objective: To observe the effect of acute hypobaric hypoxia on endothelin(ET) and nitric oxide (NO)in rats, and their correlation. Methods: Thirty six male SD rats were randomly divided into one control group and two hypoxia groups (5 000 m and 8 000 m,5 h). After seven days, the ET and NO contents of blood serum were measured. Results: The ET content in blood serum of the two hypoxia groups was significantly higher than that in the control group(P<0.05, P<0.01);the NO content in blood serum of the two hypoxia groups was significantly lower than that in the control group(P<0.05);There were no significant difference in ET and NO content in blood serum between the 5 000 m group and the 8 000 m group(P>0.05). Conclusion: It is concluded that, in vivo, acute hypobaric hypoxia may lower the NO content, and increase the ET content. |
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| Keywords: | nitric oxide(NO) endothelin(ET) acute hypobaric hypoxia |
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