| 模拟加速实验研究大黄贮藏过程中颜色变化与药效成分的相关性 |
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| 引用本文： | 李倩,何芳,艾青青,刘晓芬,连艳,兰志琼,卢先明,蒋桂华.模拟加速实验研究大黄贮藏过程中颜色变化与药效成分的相关性[J].中国实验方剂学杂志,2019,25(23):139-144. |
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| 作者姓名： | 李倩 何芳 艾青青 刘晓芬 连艳 兰志琼 卢先明 蒋桂华 |
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| 作者单位： | 成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部 共建国家重点实验室培育基地, 四川省中医药管理局中药贮藏与养护重点实验室, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部 共建国家重点实验室培育基地, 四川省中医药管理局中药贮藏与养护重点实验室, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部 共建国家重点实验室培育基地, 四川省中医药管理局中药贮藏与养护重点实验室, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部 共建国家重点实验室培育基地, 四川省中医药管理局中药贮藏与养护重点实验室, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部 共建国家重点实验室培育基地, 四川省中医药管理局中药贮藏与养护重点实验室, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部 共建国家重点实验室培育基地, 四川省中医药管理局中药贮藏与养护重点实验室, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部 共建国家重点实验室培育基地, 四川省中医药管理局中药贮藏与养护重点实验室, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部 共建国家重点实验室培育基地, 四川省中医药管理局中药贮藏与养护重点实验室, 成都 611137 |
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| 基金项目： | 国家自然科学基金国家基础科学人才培养基金项目（J1310034-07） |
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| 摘 要： | 目的:基于色度学分析原理研究大黄贮藏过程中颜色值变化与主要药效成分含量的相关性,为大黄变色机制研究及提升品质评价提供一定参考。方法:采用模拟加速试验方法,将同一批大黄药材贮藏在高温(40±5)℃,高湿RH(92. 5±5)%,强光照(4 000±500) Lx条件下加速其变色。在不同时间点取样检测,采用分光测色仪测定大黄药材粉末颜色值,采用HPLC测定大黄中总蒽醌及游离蒽醌,番泻苷A,番泻苷B以及儿茶素、没食子酸的含量,并用SPSS软件分析大黄药材中6种药效成分与颜色值之间的相关性。结果:在模拟加速实验过程中,肉眼观测到大黄药材的颜色明显地由浅变深,并逐渐变暗。根据色度值结果分析,色度值L~*,a~*,b~*,E~*ab变化趋势与儿茶素含量呈显著正相关性(P 0. 05),与游离蒽醌含量呈显著负相关性(P 0. 05),与总蒽醌及番泻苷A无相关性。色度值a~*与没食子酸含量呈显著负相关性(P 0. 05),与番泻苷B含量呈显著正相关性(P 0. 05)。结论:大黄贮藏过程中颜色值变化与6种药效成分含量存在一定的相关性。
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| 关 键 词： | 大黄 模拟加速试验 颜色变化 药效成分 相关性 |
| 收稿时间： | 2018/10/29 0:00:00 |
Simulated Accelerated Test to Study Correlation Between Color Change in Storage and Medicinal Ingredients of Rhei Radix et Rhizoma |
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| LI Qian,HE Fang,AI Qing-qing,LIU Xiao-fen,LIAN Yan,LAN Zhi-qiong,LU Xian-ming and JIANG Gui-hua.Simulated Accelerated Test to Study Correlation Between Color Change in Storage and Medicinal Ingredients of Rhei Radix et Rhizoma[J].China Journal of Experimental Traditional Medical Formulae,2019,25(23):139-144. |
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| Authors: | LI Qian HE Fang AI Qing-qing LIU Xiao-fen LIAN Yan LAN Zhi-qiong LU Xian-ming and JIANG Gui-hua |
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| Institution: | College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Key Laboratory of Chinese Materia Medica Standardization of Ministry of Education, TCM Resources System Research and Development & Utilization of Ministry of National Key Laboratory Breeding Base, Key Laboratory of TCM Storage and Maintenance, Sichuan Administration of TCM, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Key Laboratory of Chinese Materia Medica Standardization of Ministry of Education, TCM Resources System Research and Development & Utilization of Ministry of National Key Laboratory Breeding Base, Key Laboratory of TCM Storage and Maintenance, Sichuan Administration of TCM, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Key Laboratory of Chinese Materia Medica Standardization of Ministry of Education, TCM Resources System Research and Development & Utilization of Ministry of National Key Laboratory Breeding Base, Key Laboratory of TCM Storage and Maintenance, Sichuan Administration of TCM, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Key Laboratory of Chinese Materia Medica Standardization of Ministry of Education, TCM Resources System Research and Development & Utilization of Ministry of National Key Laboratory Breeding Base, Key Laboratory of TCM Storage and Maintenance, Sichuan Administration of TCM, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Key Laboratory of Chinese Materia Medica Standardization of Ministry of Education, TCM Resources System Research and Development & Utilization of Ministry of National Key Laboratory Breeding Base, Key Laboratory of TCM Storage and Maintenance, Sichuan Administration of TCM, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Key Laboratory of Chinese Materia Medica Standardization of Ministry of Education, TCM Resources System Research and Development & Utilization of Ministry of National Key Laboratory Breeding Base, Key Laboratory of TCM Storage and Maintenance, Sichuan Administration of TCM, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Key Laboratory of Chinese Materia Medica Standardization of Ministry of Education, TCM Resources System Research and Development & Utilization of Ministry of National Key Laboratory Breeding Base, Key Laboratory of TCM Storage and Maintenance, Sichuan Administration of TCM, Chengdu 611137, China and College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Key Laboratory of Chinese Materia Medica Standardization of Ministry of Education, TCM Resources System Research and Development & Utilization of Ministry of National Key Laboratory Breeding Base, Key Laboratory of TCM Storage and Maintenance, Sichuan Administration of TCM, Chengdu 611137, China |
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| Abstract: | |
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| Keywords: | Rhei Radix et Rhizoma simulated acceleration test color change medicinal ingredients correlation |
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