中药诱导肝癌细胞自噬特点分析及意义

中药及其成分在抗肝癌领域发挥着重要作用,从细胞自噬角度阐明其作用机制,有助于中医药在抗肝癌领域研究的发展。该文通过文献分析归纳,发现中药及其有效成分有促进自噬诱导肿瘤细胞凋亡和周期抑制的报道,也有抑制自噬阻滞肿瘤细胞周期的报道,但缺乏系统整理。该文根据中药诱导肝癌细胞自噬发挥作用的不同,从诱导杀伤性自噬、抑制保护性自噬、诱导肝癌保护性自噬、诱导效应不明自噬4方面进行归纳分析中药及其成分。发现引起杀伤性自噬的中药及成分,可通过诱导自噬的发生、阻滞细胞周期、诱导细胞衰老或促进细胞凋亡;抑制保护性自噬的中药及成分,通过抑制保护性自噬进而抑制肝癌细胞增殖;诱导保护性自噬的中药及成分具有显著抗肝癌作用,应考虑联合应用自噬抑制剂,增强药物对肝癌细胞的杀伤力,成为该类药物治疗肝癌的新途径;诱导效应不明自噬中药及成分,需明确其自噬的类型,根据自噬类型联合应用自噬激动剂或阻断剂以增强其抗肝癌效应,为临床肝癌的治疗提供新治疗途径。从细胞自噬方面不仅可揭示中药抗肝癌的分子机制,也可成为中药联合用药抗肝癌研究的新途径。

Analysis and Significance of Autophagy in Liver Cancer Cells Induced by Traditional Chinese Medicine

Traditional Chinese medicine(TCM) and its components play a role in the field of anti-hepatocarcinoma. The definition of its mechanism of action in autophagy contributes to the development of TCM in the field of anti-hepatocarcinoma. In this paper, we summarized reports on the autophagy of liver cancer cells induced by TCM and its active ingredients, including those on promoting apoptosis and cycle inhibition induced by autophagy and inhibiting autophagy to block tumor cell cycle, but with a lack of systematic summarization. In this paper, according to different effect of TCM on autophagy induced by hepatocarcinoma, the TCM and its components were inductively analyzed in four aspects:inducing killing autophagy, inhibiting protective autophagy, inducing protective autophagy in liver cancer, and inducing unclear autophagy. According to the findings, TCMs and components that cause killing autophagy can inhibit the occurrence of autophagy, arrest cell cycle, induce cell senescence or promote apoptosis. TCMs and components that inhibit protective autophagy can inhibit protective autophagy and hepatoma cell proliferation. TCMs and components that induce protective autophagy have a significant anti-hepatocarcinoma effect, shall be considered to be combined with autophagy inhibitors to enhance the lethality of drugs on liver cancer cells, and become a new way for such drugs to treat liver cancer. TCMs and components with an unclear inductive effect shall be first identified for their type of autophagy, then combined with autophagy agonists or blockers according to the type of autophagy to enhance their anti-liver cancer effect, and provide a new clinical therapeutic approach for liver cancer. In the aspect of autophagy, this study not only reveals the molecular mechanism of anti-hepatocarcinoma of TCM, but also makes it a new way to study anti-hepatocarcinoma by TCM.