自身免疫性脑炎患者体内NMDAR, CASPR和GABAbR在免疫球蛋白与激素联合治疗后的变化

探讨自身免疫性脑炎患者体内抗N-甲基-D-天冬氨酸受体(NMDAR)受体抗体脑炎、抗γ-氨基丁酸B受体(GABABR)抗体脑炎、抗接触蛋白相关蛋白样蛋白2(CASPR2)在免疫球蛋白与激素联合治疗后的变化研究。70例接受免疫球蛋白联合激素药物治疗的自身免疫性脑炎患者,检测药物治疗前后患者血清和脑脊液中NMDAR、CASPR2和GABABR的浓度变化进行比较分析。抗NMDAR脑炎患者血清和脑脊液NMDAR浓度显著下降；抗CASPR2脑炎患者血清和脑脊液CASPR2浓度显著下降；抗GABABR脑炎患者血清和脑脊液GABABR明显上升(P<0.05)。不同类型自身免疫性脑炎患者体内NMDAR,CASPR2和GABABR含量呈异常状态；临床应用免疫球蛋白与激素联合治疗可以有效缓解及治疗自身免疫性脑炎疾病。

Changes of NMDAR, CASPR and GABAbR in patients with autoimmune encephalitis after combined immunoglobulin and hormone therapy

To investigate the changes and significance of Anti-N-methyl-D-aspartate receptor (NMDAR) receptor antibody encephalitis, anti-gamma-aminobutyric acid B receptor (GABABR) antibody encephalitis, anti-contact protein-associated protein-like protein 2 (CASPR2) in patients with different types of autoimmune encephalitis after combined treatment of immunoglobulin and hormones. 70 cases of patients with autoimmune encephalitis were treated with immunoglobulin and hormone therapy. The concentrations of NMDAR, CASPR2, and GABABR in serum and cerebrospinal fluid before and after drug treatment were compared and analyzed. Serum NMDAR concentrations in patients with anti-NMDAR encephalitis significantly decreased after treatment; CASPR2 concentrations in serum and cerebrospinal fluid of patients with anti-CASPR2 encephalitis decreased significantly; GABABR in serum and cerebrospinal fluid of patients with anti-GABABR encephalitis increased significantly (P<0.05). The levels of NMDAR, CASPR2 and GABABR in patients with different types of autoimmune encephalitis are abnormal. The combination of clinical use of immunoglobulin and hormone can effectively relieve and treat autoimmune encephalitis diseases.