多成分体系下中药活性成分生物药剂学研究进展

药物生物药剂学属性(溶解性、渗透性等)在了解药物体内过程、筛选药物、评价给药系统等方面发挥着越来越重要的作用。中药活性成分复杂、结构类型多样,生物药剂学为中药成分体内过程的预测与研究提供了思路与途径。多成分体系是中药与化学药物的主要区别之一,多成分体系下的中药活性成分的生物药剂学分析已成为研究热点之一,笔者对中药多成分体系下生物药剂学分类系统的构建现状和应用情况进行综述,以期为该领域数据整合、理论归纳以及系统构建提供参考,并为中药传统理论研究以及药品的开发提供新思路。

Research Progress on Biopharmaceutics of Active Ingredients in Chinese Materia Medica Under Multi-component System

The biopharmaceutical properties (solubility, permeability, etc.) of active pharmaceutical ingredients are playing an important role in understanding of disposition of drugs in the body, screening of drugs and evaluation of drug delivery system. The active ingredients of Chinese materia medica (CMM) are various and complex, the research on biopharmaceutics provides a train of thought and practical method for the prediction and research on the process of active ingredients from CMM in vivo. The multi-components system is one of the main differences between CMM and chemical medicine, and the study on biopharmaceutics of active ingredients in CMM under multi-components system has become a hot topic. The progress on biopharmaceutics of active ingredients in CMM under multi-components system was reviewed in this article, which may provide the reference for data integration, theoretical induction and system construction in this field, and provide new train of thought for the research on CMM theories and the development of CMM in the perspective of biopharmaceutics.