棕榈酸羟基硬脂酸抗代谢性炎症综合征作用机制的研究进展

老年代谢性炎症综合征(MIS)患病率高,患者体内普遍存在糖脂代谢紊乱和胰岛素抵抗,而新型化合物——羟基脂肪酸支链脂肪酸酯(FAHFAs)具有增强胰岛素敏感性和抗炎作用,其中棕榈酸羟基硬脂酸(PAHSA)是含量最高的一种同分异构体。体内PAHSA水平的改变主要受碳水化合物反应元件结合蛋白(CHREBP)的调节,并通过G蛋白偶联受体120(GPR120)发挥生物学效应。本文主要就PAHSA抗MIS的作用机制研究进展作一综述。

Research progress on mechanism of palmitic acid hydroxy stearic accid in anti-metabolic inflammatory syndrome

The prevalence of metabolic inflammatory syndrome (MIS) in the elderly is high, and imbalance of glucose and lipid homeostasis and insulin resistance are common in these patients. The novel compound, branched fatty acid esters of hydroxy fatty acids (FAHFAs), has effects of enhancing insulin sensitivity and anti-inflammatory, among which the content of palmitic acid hydroxy stearic acid (PAHSA) is the highest. The level of PAHSA in vivo is primarily regulated by the carbohydrate response element binding protein (CHREBP), which exerts a biological effects via G protein coupled receptor 120 (GPR120). This review mainly describes the research progress on the mechanism of PAHSA in metabolic inflammatory syndrome.