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关于子宫内膜异位症发病机制与肠道菌群关系的思考
引用本文:胡小松,孙宇峰,李婷,刘敬阁,刘春生.关于子宫内膜异位症发病机制与肠道菌群关系的思考[J].中国实验方剂学杂志,2019,25(6):196-203.
作者姓名:胡小松  孙宇峰  李婷  刘敬阁  刘春生
作者单位:北京中医药大学 中药学院, 北京 100029,北京中医药大学 中药学院, 北京 100029,北京中医药大学 中药学院, 北京 100029,尚方堂中药有限公司, 兰州 730030,北京中医药大学 中药学院, 北京 100029
基金项目:国家公益性行业科研专项(201507002);尚方堂中药有限公司-北京中医药大学横向课题——中药材五灵脂的菌群测定及菌群库的建立(2017110031012434)
摘    要:子宫内膜异位症(简称内异症)作为困扰育龄期女性健康的多发性疾病,近几年来发病率逐年上升,且趋于年轻化。目前,内异症的发病机制尚不完全清楚,治愈率不高且极易复发。近年来研究表明人体是由大量微生物组成的共生体,尤其是肠道内微生物与机体健康密切相关。该文以内异症前期研究为基础,提出其发病机制可能与患者肠道微生物紊乱有关,为寻找内异症的治疗方法提供新思路与参考。

关 键 词:子宫内膜异位症  肠道菌群失调  细菌内毒素  上皮-间质转化  免疫耐受  脂多糖  癥瘕
收稿时间:2018/3/19 0:00:00

Reflections on Relationship Between Pathogenesis of Endometriosis and Intestinal Flora
HU Xiao-song,SUN Yu-feng,LI Ting,LIU Jing-ge and LIU Chun-sheng.Reflections on Relationship Between Pathogenesis of Endometriosis and Intestinal Flora[J].China Journal of Experimental Traditional Medical Formulae,2019,25(6):196-203.
Authors:HU Xiao-song  SUN Yu-feng  LI Ting  LIU Jing-ge and LIU Chun-sheng
Institution:School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China,Shangfangtang Chinese Medicine Co. Ltd., Lanzhou 730030, China and School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
Abstract:Endometriosis is a multiple disease that afflicts the health of women at childbearing age,and its incidence rate has been increasing year by year,furthermore,there has been a trend to be younger.At present,the pathogenesis of endometriosis has been not expounded completely,its cure rate is not high with high recurrence rate.In recent years,studies have shown that the human is a commensal body composed of a large number of microorganisms,and especially the microorganisms in the intestinal are closely related to the health of the body.Based on the previous studies on endometriosis,this paper proposes that its pathogenesis may be related to intestinal microbiological disorder,and aims to provide new ideas for the treatment of endometriosis.
Keywords:endometriosis  intestinal flora imbalance  bacterial endotoxin  epithelial-mesenchymal transition  immunotolerance  lipopolysaccharide  pelvic mass
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