Extracellular matrix protein ITGBL1 promotes ovarian cancer cell migration and adhesion through Wnt/PCP signaling and FAK/SRC pathway |
| |
| Affiliation: | 1. Department of Out-patient, Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei Province, China;2. Department of Endocrinology, Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei Province, China;3. Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei Province, China;4. Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories 999077, Hong Kong, China;5. College of Biology, Hunan University, Changsha 410082, China;1. College of Information Sciences and Automation Research Institute, Bohai University, Jinzhou, Liaoning 121013, PR China;2. College of Mathematics and Physics and Automation Research Institute, Bohai University, Jinzhou, Liaoning 121013, PR China;1. Department of Medicine, Division of Endocrinology, St. Paul''s Hospital & University of British Columbia, Vancouver, BC, Canada;2. Department of Surgery, St. Paul''s Hospital & University of British Columbia, Vancouver, BC, Canada;3. Department of Radiology, St. Paul''s Hospital & University of British Columbia, Vancouver, BC, Canada;1. Department of Othopedics, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Road, Zhengzhou, 450000 Henan, PR China;2. Department of Orthopaedics, The No.3 People’s Hospital of Anyang City, Anyang 455000, PR China;1. Department of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, No.1 Min De Road, Nanchang, China;2. The Medical School of Nanchang University, Nanchang, China;3. Departments of Clinical Laboratory, the First Affiliated Hospital of Nanchang University, Nanchang, China |
| |
| Abstract: | Despite the advances in cancer treatment and the progresses in tumor biological, ovarian cancer remains a bad situation. In current study, we found a novel extracellular matrix protein, ITGBL1, which is highly expressed in ovarian cancer tissues by immunohistochemistry examination. The expression pattern of ITGBL1 in malignant tissues inspired us to investigate its role in ovarian cancer progression. Both loss- and gain-function assays revealed that ITGBL1 could promote ovarian cancer cell migration and adhesion. As it’s a secreted protein, we further used recombinant ITGBL1 protein treated cancer cells and found that ITGBL1 promotes cell migration and adhesion in a concentration dependent manner. Furthermore, we found that ITGBL1 not only influences the activity of Wnt/PCP signaling but also affects FAK/src pathway in vitro. Taken together, our results suggest that highly expressed ITGBL1 could promotes cancer cell migration and adhesion in ovarian cancer and as a secreted protein, ITGBL1 might be a novel biomarker for ovarian cancer diagnosis. |
| |
| Keywords: | ITGBL1 Ovarian cancer Migration and adhesion Wnt/PCP signaling RhoA FAK/src pathway |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
