Commentary on the 2016 named series: Neuroimaging,inflammation and behavior |
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| Affiliation: | 1. Mitochondrial Research Group, University of Newcastle Upon Tyne, United Kingdom;2. Institute for Ageing and Health, University of Newcastle Upon Tyne, United Kingdom;1. School of Mechanical Engineering, Southwest Jiaotong University, 610031 Chengdu, PR China;2. School of Industrial Technology and Business Studies, Dalarna University, SE-79188 Falun, Sweden;1. Division of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA;2. Division of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA;3. Division of Infectious Disease, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA;4. Vaccine Center, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA;5. Department of Dermatology, New York University Langone Health, New York, NY, USA;6. Department of Population Health, New York University Langone Health, New York, NY, USA |
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| Abstract: | Neuroimaging techniques are increasingly used to characterize the neural circuitry mediating actions of inflammation on mood, motivation, and cognition and its relationship to common mental illnesses, particularly major depressive disorder (MDD). In addition, imaging techniques such as single photon emission tomography (SPECT), positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) can index effects of inflammation on specific neurotransmitters, monoamine transporters, metabolites and even activation of discrete cells such as microglia. The special named series ‘Neuroimaging, inflammation and behavior’ illustrates the power of neuroimaging techniques to characterize discrete actions of inflammation on the brain at neurochemical, cellular, regional and network levels. Combined with careful cognitive assessment and pre-clinical studies, diverse neuroimaging techniques are helping clarify the mechanisms through which inflammation acts on the brain to reorient behavior and predispose to mental and physical illnesses. |
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| Keywords: | Anxiety Depression Imaging Inflammation MRI MRS PET SPECT |
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