Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial |
| |
| Institution: | 1. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;2. Department of Endocrinology, Baqiyatallah university of Medical Sciences, Tehran, Iran;3. Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico;4. Sabinsa Inc., Princeton, NJ, United States;5. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;6. Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia;1. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department of Nutritional Sciences, University of Connecticut, Storrs, CT, United States;3. Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland;4. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland;5. Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy;6. Sabinsa Corporation, East Windsor, NJ, United States;7. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;8. School of Medicine, University of Western Australia, Perth, Australia;1. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department of Pharmacology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand;3. Department of Pharmacology & Toxicology, School of Biomedical Sciences, Department of Chemistry, University of Otago, Dunedin, New Zealand;4. Sabinsa Corporation, East Windsor, NJ, United States;5. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;6. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran;7. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;8. Halal Research Center of IRI, FDA, Tehran, Iran;9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran;10. Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;1. Chronic Kidney Disease Research Center (CKDRC), Department of Nephrology, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;1. Student Research Committee, Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy;3. Sabinsa Inc, Princeton, NJ, United States;4. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;1. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;2. Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia;3. Medicine and Surgery Sciences Dept.,University of Bologna, Italy;4. Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico;5. Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX USA;6. Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, India;1. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;2. Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran;3. Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;4. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran |
| |
| Abstract: | BackgroundCytokines are involved in the development of metabolic abnormalities that may result in metabolic syndrome (MetS). Since curcumin has shown anti-inflammatory properties, the aim of this study was to evaluate the effect of curcumin supplementation on serum cytokines concentrations in subjects with MetS.MethodsThis study was a post-hoc analysis of a randomized controlled trial in which males and females with diagnosis of MetS, according to the criteria defined by the National Cholesterol Education Program Adult Treatment Panel III guidelines, were studied. Subjects who met the inclusion criteria were randomly assigned to either curcumin (daily dose of 1 g/day) or a matched placebo for a period of 8 weeks.ResultsOne hundred and seventeen subjects were assigned to either curcumin (n = 59) or placebo (n = 58) groups. Within-group analysis revealed significant reductions in serum concentrations of TNF-α, IL-6, TGF-β and MCP-1 following curcumin supplementation (p < 0.001). In the placebo group, serum levels of TGF-β were decreased (p = 0.003) but those of IL-6 (p = 0.735), TNF-α (p = 0.138) and MCP-1 (p = 0.832) remained unaltered by the end of study. Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-α, IL-6, TGF-β and MCP-1 in the curcumin versus placebo group (p < 0.001). Apart from IL-6, changes in other parameters remained statistically significant after adjustment for potential confounders including changes in serum lipids and glucose levels, and baseline serum concentration of the cytokines.ConclusionResults of the present study suggest that curcumin supplementation significantly decreases serum concentrations of pro-inflammatory cytokines in subjects with MetS. |
| |
| Keywords: | Curcuminoids Cytokines Cardiovascular Inflammation Randomized controlled trial |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
