Turkish propolis supresses MCF-7 cell death induced by homocysteine |
| |
| Institution: | 1. Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Bingol University, 12000 Bingol, Turkey;2. Council of Higher Education, 06539, Bilkent, Ankara, Turkey;1. West University of Timisoara, Timisoara, Romania;2. Joint Institute for Nuclear Research, Dubna 141980, Russian Federation;3. Horia Hulubei National Institute of Physics and Nuclear Engineering, Bucharest-Magurele, Romania;1. The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China;2. Guangxi Medical University, Nanning 530021, China;3. Department of Biochemistry, University of Arkansas Medical School, 4301W. Markham, Little Rock, AR 72205-7199, USA;1. Shandong Jining NO.1 People’s Hospital, Jining, PR China;2. Jining Medical University, Jining, PR China;1. Department of Translational Research and New Technologies in Medicine and Surgery, Pharmacology, Medical School, University of Pisa, Via Roma 55, 56126, Pisa, Italy;2. Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126, Pisa, Italy;1. Department of Medical Oncology, Institute of Oncology, Istanbul University Capa, 34093 Istanbul, Turkey;2. Department of Basic Oncology, Institute of Oncology, Istanbul University Capa, 34093 Istanbul, Turkey;1. School of Fundamental Science, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Malaysia;2. Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Malaysia |
| |
| Abstract: | Elevated plasma homocysteine (Hcy) level is a most important risk factor for various vascular diseases including coronary, cerebral and peripheral arterial and venous thrombosis.Propolis is produced by honeybee from various oils, pollens and wax materials. Therefore, it has various biological properties including antioxidant, antitumor and antimicrobial activities.This study investigated the effects of propolis and Hcy on apoptosis in cancer cells. According to our findings, Hcy induced apoptosis in human breast adenocarcinoma (MCF-7) cells by regulating numerous genes and proteins involved in the apoptotic signal transduction pathway. In contrast, treatment with propolis inhibited caspase- 3 and ?9 induced by Hcy in MCF-7 cells. It can be concluded that Hcy may augment the activity of anticancer agents that induce excessive reactive oxygen species (ROS) generation and apoptosis in their target cells. In contrast to the previous studies herein we found that propolis in low doses protected cancer cells inhibiting cellular apoptosis mediated by intracellular ROS-dependent mitochondrial pathway. |
| |
| Keywords: | Propolis Homocysteine MCF-7 LPO ROS cDNA |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
