| ATF4作用机制与相关疾病的研究进展 |
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| 引用本文： | 任梓瑞,鲍计章,李洋. ATF4作用机制与相关疾病的研究进展[J]. 中国现代医学杂志, 2023, 0(21): 58-63 |
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| 作者姓名： | 任梓瑞 鲍计章 李洋 |
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| 作者单位： | 1.上海中医药大学附属岳阳中西医结合医院, 上海 200437;2.上海中医药大学附属市中医医院, 上海 200071 |
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| 基金项目： | 上海市科技计划项目（No：22Y11921100）;上海市中医医院未来计划（2021年）传承人才项目（No：WLJH2021ZY-MZY033）;上海中医药大学高峰高原学科（临床人才专项）项目;上海市中医医院未来计划（No：WL-XJRY-2021004K）;中国民族医药学会科研项目（No：2020ZY366-440401）。 |
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| 摘 要： | 激活转录因子4(ATF4)是激活转录因子中的一种基因,其功能多样,作用范围广,参与作用多种生物学过程。该文介绍ATF4在生理机制、疾病发展过程及治疗靶点中相关功能的研究进展,为其在心脑血管疾病、肿瘤、血液系统疾病中的应用提供理论支持及新思路。
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| 关 键 词： | 激活转录因子4 心脑血管疾病 肿瘤微环境 血液系统疾病 |
| 收稿时间： | 2023-02-03 |
Research progress of ATF4 gene |
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| Ren Zi-rui,Bao Ji-zhang,Li Yang. Research progress of ATF4 gene[J]. China Journal of Modern Medicine, 2023, 0(21): 58-63 |
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| Authors: | Ren Zi-rui Bao Ji-zhang Li Yang |
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| Affiliation: | 1.Yueyang Hospital of intergrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China;2.Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China |
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| Abstract: | Activating transcription factor 4 (ATF4) is one of the genes that activate transcription factors. It has diverse functions and a wide range of functions. Multiple biological processes have to be involved with ATF4. This paper presents the progress of research on the functions of ATF4 in physiological mechanisms, disease development processes and therapeutic targets. It is expected to provide theoretical support and new ideas for the application of this gene in cardiovascular and cerebrovascular diseases, tumors, and hematologic diseases. |
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| Keywords: | activating transcription factor 4 cardiovascular and cerebrovascular diseases tumor microenvironment hematological disorders |
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